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Peptides  >  p53 Peptides  >>  [Lys(Me2)372]-p53 (368-393), p53 K372(Me2), biotin-labeled, human

Product Name [Lys(Me2)372] - p53 (368 - 393), p53 K372(Me2), biotin - labeled, human
Biotin - KGGHLKS - K(Me2) - KGQSTSRHKKLMFKTEGPDSD - NH2
Size 1 mg
Catalog # 64867-1
US$ $385
Purity % Peak Area By HPLC ≥ 95%
Description

This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with dimethylation at Lys372 and additional KGW residues on its N-terminus. Methylation at Lys372 activates p53 and induces upregulation of target gene p21. Methylation at Lys372 also inhibits Lys370 methylation by interfering with Smyd2, a lysine methyltransferase, and p53 interaction. Lys 370 methylation reduces p53 transcriptional targets.

Storage -20C
References Huang, J. et al. Nature 440, 629 (2006).
Molecular Weight 3467
Sequence
(One-Letter Code)
Biotin-KGGHLKS-K(Me2)-KGQSTSRHKKLMFKTEGPDSD-NH2
Sequence
(Three-Letter Code)
Biotin - Lys - Gly - Gly - His - Leu - Lys - Ser - Lys(Me2) - Lys - Gly - Gln - Ser - Thr - Ser - Arg - His - Lys - Lys - Leu - Met - Phe - Lys - Thr - Glu - Gly - Pro - Asp - Ser - Asp - NH2
     
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