This peptide is histone H4 (1-23) symmetrically dimethylated at Arg3 followed by a biotinylated Lys conjugated to a C-terminal GG linker. Methylation of Arg3 is catalyzed by PRMT1 and functions to promote p300 acetylation of histone H4. It has also been shown to regulate transcriptional activation of genes involved in cholesterol and bile acid homeostasis. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Rizzo, G. et al. Mol Pharmacol68, 551 (2005); Wang, H. et al. Science293, 853 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg(Me2s) - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - Val - Leu - Arg - Gly - Gly - Lys(Biotin) - OH