IMG-EN-AS-65248-1-01.jpg
Peptides

[Lys(Ac) 5/8/12/16]-Histone H4 (1-25)-GSGSK(Biotin) - 1 mg

$473.00
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  • Cat.Number : AS-65248-1
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    In stock

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This peptide is histone H4 (1-25) with acetylation at Lys5, Lys8, Lys12, and Lys16, followed by a C-terminal GSGS linker and a biotinylated lysine. Acetylation at Lys5, Lys8, and Lys12 is carried out by p300 protein while acetylation at Lys16 is regulated by several histone acetyltransferases. These lysine residues have been shown to have important functions in transcriptional activation, replication, and nuclear division. Acetylation of lysine residues promotes binding of transcription factors to histone H4. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVLRDN-GSGSK(Biotin)
Sequence three letter code
  • H-Ser-Gly-Arg-Gly-Lys(Ac)-Gly-Gly-Lys(Ac)-Gly-Leu-Gly-Lys(Ac)-Gly-Gly-Ala-Lys(Ac)-Arg-His-Arg-Lys-Val-Leu-Arg-Asp-Asn-Gly-Ser-Gly-Ser-Lys(Biotin)-OH
Molecular Mass/ Weight
  • 3401
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro

EMBO J . 1996 May 15 ; 15(10) 2508 | DOI : https://doi.org/10.1002/j.1460-2075.1996.tb00608.x

  • M. Vettese-Dadey
  • et al

Genetic Analysis of Histone H4: Essential Role of Lysines Subject to Reversible Acetylation

Science . 1990 Feb 16 ; 247(4944) 841 | DOI : 10.1126/science.2106160

  • PC. Megee
  • et al