This peptide is histone H4 (1-25) with acetylation at Lys16. It is biotinylated through a C-terminal GSGSK linker. Monoacetylation of histone H4 occurs predominantly at Lys16. Loss of monoacetylation at Lys16 is associated with human tumor cells. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Fraga, M. et al. Nat Genet37, 391 (2005); Carmen, A. et al. J Biol Chem277, 4778 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys(Ac) - Arg - His - Arg - Lys - Val - Leu - Arg - Asp - Asn - Gly - Ser - Gly - Ser - Lys(Biotin) - OH