This peptide is histone H4 (1-25) with acetylation at Lys8. It is biotinylated through a C-terminal GSGSK linker. Acetylation at Lys8 is crucial to the recruitment of the SWI/SNF (switch/sucrose non-fermenting) chromatin-remodeling complex through the bromodomain-containing protein BRG1 for transcriptional activation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Kurdistani, S. and M. Grunstein Nat Rev Mol Cell Biol4, 276 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys(Ac) - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - Val - Leu - Arg - Asp - Asn - Gly - Ser - Gly - Ser - Lys(Biotin) - OH