This peptide is histone H3 (15-36) asymmetrically dimethylated at Arg26, followed by a C-terminal GGK with biotinylation on the side chain of Lys. Dimethylation at Arg26 is catalyzed by CARM1 and inhibits deimination by peptidylarginine deiminase (PADI)-4. Arginine methylation of histone H3 is associated with transcriptional activation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Cuthbert, G. et al. Cell118, 545 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Thr - Lys - Ala - Ala - Arg(Me2a) - Lys - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Val - Lys - Gly - Gly - Lys(Biotin) - OH