IMG-EN-AS-65226-1-01.jpg
Peptides

[Lys(Ac)12/16, Lys(Me3)20]-Histone H4 (1-25)-GSGSK(Biotin) - 1 mg

$430.00
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  • Cat.Number : AS-65226-1
  • Availability :
    In stock

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This peptide is histone H4 (1-25) with acetylation at Lys12 and Lys16 and trimethylation at Lys20, followed by a C-terminal GSGS linker and a biotinylated Lys. Trimethylation at Lys20 of histone H4 is catalyzed by Suv4-20 and is involved in transcriptional silencing and heterochromatin formation in eukaryotes. It has been shown that histone H4 is preferentially acetylated first at Lys16, then at Lys12. Diacetylated histone H4 has been shown to bind repressor protein TUP1. Acetylation of histone H4 also regulates heterochromatin formation by promoting the binding of bromodomains to p300 and transcription factor TAFII250 and inhibiting interactions with SIR3. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • SGRGKGGKGLG-K(Ac)-GGA-K(Ac)-RHR-K(Me3)-VLRDN-GSGSK(Biotin)
Sequence three letter code
  • H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys(Ac)-Gly-Gly-Ala-Lys(Ac)-Arg-His-Arg-Lys(Me3)-Val-Leu-Arg-Asp-Asn-Gly-Ser-Gly-Ser-Lys(Biotin)-OH
Molecular Mass/ Weight
  • 3360
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Acetylation of the Yeast Histone H4 N Terminus Regulates Its Binding to Heterochromatin Protein SIR3

J Biol Chem . 2002 Feb 01 ; 277(7) 4778 | DOI : https://doi.org/10.1074/jbc.M110532200

  • A. Carmen
  • et al

Histone H4 acetylation in human cells Frequency of acetylation at different sites defined by immunolabeling with site-specific antibodies

FEBS Lett . 1989 Jan 01 ; 253(1-2) 141 | DOI : https://doi.org/10.1016/0014-5793(89)80947-0

  • B. Turner
  • et al

Oncogenes and senescence: breaking down in the fast lane

Gene Dev . 2007 Jan 01 ; 21 1 | DOI : 10.1101/gad.1514207

  • M. Hemann
  • M. Narita