This is a monomethylated lysine at position 4 of the 1-21 amino acid histone H3 peptide. This form of histone methylation is characterized as being enriched around transcription start sites. Itís chromatin mark was also closely correlated to cell-type specific expression of putative gene targets of enhancers. It was also noted from a genome wide study that most potential regulatory elements were enriched only by the mono-methylated version of this histone 3.
The short peptide RGDS (Arg-Gly-Asp-Ser) is a synthetic cell adhesion factor. RGDS is known to mediate cell adhesion to several extracellular matrix components as well as cellĖcell interactions. The RGDS peptide has been shown to interact directly with and activates caspases 8 and 9, which indicates an unexpected pro-apoptotic effect due to an intracellular action.
1, Tian Y. et al. PLOS One. 6(11):e27770 (2011). 2, Ortega-Velazquez, R. et al. FASEB. 17, 1529 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys(Me1) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - OH