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Peptides  >  Cyclic Peptides  >   Disulfide Cyclized Peptides  >>  hBD-4, β-Defensin-4, human

Product Name hBD - 4, β - Defensin - 4, human
ELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRK (Disulfide bridge: 6 - 33; 13 - 27; 17 - 34)
Size 0.1 mg
Catalog # AS-60742
US$ $303
Purity % Peak Area By HPLC ≥ 95%
Description

This is a 4.4kDa 37-amino acid antimicrobial peptide called beta-Defensin-4 (hBD-4) having a beta sheet with three intramolecular disulfide bonds. Its expression is inducible in primary keratinocytes but not from healthy human skin. High levels of hBD-4 were detected in testis and in gastric antrum and low levels were found in neutrophils and in the epithelia of the thyroid gland, lungs, uterus and kidney. It can be stimulated by heat-inactivated P. aeruginosa or S. pneumoniae in human respiratory epithelial cells. In addition, it's expression is increased after exposure to PMA and bacteria but not IL-1alpha, IL-6, IFN_gamma or TNF-alpha, which are believed as common inducers of hBDs. Like hBDs-1 and 2, hBD-4 is salt-sensitive in eliciting its antimicrobial activity. With lysozyme it shows a synergistic killing activity of S. carnosus. Similar to hBD-2, it elicits cytokine production by keratinocytes and induces monocyte chemotaxis.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
References 1, Niyonsaba F and Ogawa H. J Derm Sci. 40, 157-168 (2005).
2, Cole, A. Protein and Peptide Lett 12, 41 (2005).
Molecular Weight 4366.1
Sequence
(One-Letter Code)
ELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRK (Disulfide bridge: 6-33; 13-27; 17-34)
Sequence
(Three-Letter Code)
H - Glu - Leu - Asp - Arg - Ile - Cys - Gly - Tyr - Gly - Thr - Ala - Arg - Cys - Arg - Lys - Lys - Cys - Arg - Ser - Gln - Glu - Tyr - Arg - Ile - Gly - Arg - Cys - Pro - Asn - Thr - Tyr - Ala - Cys - Cys - Leu - Arg - Lys - OH (Disulfide bridge: 6 - 33; 13 - 27; 17 - 34)
Product Citations Mount, KLB. et al. (2007). Haemophilus ducreyi is resistant to human antimicrobial peptides. Antimicrob Agents Chemo 51 3391. doi: 10.1128/AAC.00473-07
     
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