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Peptides  >  Apoptosis Peptides  >>  Caspase 1 (ICE) Substrate 3f, fluorogenic

Product Name Caspase 1 (ICE) Substrate 3f, fluorogenic
Ac - WEHD - AFC
Size 5 mg
Catalog # AS-25285-5
US$ $181
Description

AFC (7-amino-4-trifluoromethylcoumarin)-derived caspase substrates are widely used for the fluorimetric detection of various caspase activities. Cleavage of AFC peptides by caspases generate strongly fluorescent AFC that is monitored fluorimetrically at 500-510 nm with excitation of 370-390 nm.

Caspase-1 substrate

Detailed Information Datasheet
Storage -20C desiccated and protected from light
References 1, Gurtu V, et al. Anal Biochem 251, 98-102 (1997).; 2. Martins LM, et al. J Biol Chem 272, 7421-30 (1997).; 3. Deveraux QL, et al. Nature 388, 300-4 (1997).; 4. Xiang J, et al. Proc Natl Acad Sci USA 93, 14559-63 (1996).
Molecular Weight 838.6
Sequence
(One-Letter Code)
Ac-WEHD-AFC
Sequence
(Three-Letter Code)
Ac - Trp - Glu - His - Asp - AFC
Product Citations Liao, YH. et al. (2013). HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation. J Leukoc Biol 93, 289. doi: 10.1189/jlb.0812409.
     
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