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Peptides  >  Apoptosis Peptides  >>  Bid BH3-R8

Product Name Bid BH3 - R8
RRRRRRRRGEDIIRNIARHLAQVGDSMDR
Size 1 mg
Catalog # 62057
US$ $231
Purity % Peak Area By HPLC ≥ 95%
Description

Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. BID BH3 interacts with Bax to induce mitochondrial outer membrane permeabilization in the apoptotic process. This peptide contains 8 Arg residues in the L-isomeric form on the N-terminus. BID Tagging with poly-arginine facilitates cell internalization. R8BIDH3 has been shown to induce apoptosis of Jurkat leukemia cells in vitro.

Storage -20C
References Letai, A. J Clin Invest 115, 2648 (2005). Goldsmith, K. et al. Proc Amer Assoc Cancer Res 45,1829 (2004). Goldsmith, K. et al. Oncogene 25, 4525 (2006).
Molecular Weight 3616.2
Sequence
(One-Letter Code)
RRRRRRRRGEDIIRNIARHLAQVGDSMDR
Sequence
(Three-Letter Code)
H - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Gly - Glu - Asp - Ile - Ile - Arg - Asn - Ile - Ala - Arg - His - Leu - Ala - Gln - Val - Gly - Asp - Ser - Met - Asp - Arg - OH
     
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