Bid BH3 is a pro-apoptotic member of the "BH3-only" subset of BCL-2 family proteins that constitute a critical control point in apoptosis. BID BH3 interacts with Bax to induce mitochondrial outer membrane permeabilization in the apoptotic process. This peptide contains 8 Arg residues in the L-isomeric form on the N-terminus. BID Tagging with poly-arginine facilitates cell internalization. R8BIDH3 has been shown to induce apoptosis of Jurkat leukemia cells in vitro.
Letai, A. J Clin Invest115, 2648 (2005). Goldsmith, K. et al. Proc Amer Assoc Cancer Res45,1829 (2004). Goldsmith, K. et al. Oncogene25, 4525 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Gly - Glu - Asp - Ile - Ile - Arg - Asn - Ile - Ala - Arg - His - Leu - Ala - Gln - Val - Gly - Asp - Ser - Met - Asp - Arg - OH