This is a monomethylated lysine at position 9 of the 1-21 amino acid histone H3 peptide. This form of histone methylation is characterized as being enriched around transcription start sites. This peptide has been used as a control peptide in a TR-FRET assay for identifying inhibitors of histone lysine demethylases.
1, Tian Y. et al. PLOS One. 6(11):e27770 (2011) 2, Yu V. et al. J Biomol Screen. 1791):27-38 (2011).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys(Me1) - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - OH