IMG-EN-AS-60130-1-01.jpg
Peptides

MOG (35-55), mouse, rat

$182.00
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  • Cat.Number : AS-60130-1
  • Availability :
    In stock

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Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system. MOG (35-55) is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. Autoantibody response to MOG (35-55) has been observed in multiple sclerosis (MS) patients and MOG (35-55)-induced experimental autoimmune encephalomyelitis (EAE) C57/BL6 mice and Lewis rats. Every lot of MOG (35-55) peptide is tested and proven to induce EAE.

Specifications

Chemistry
Sequence one letter code
  • MEVGWYRSPFSRVVHLYRNGK
Sequence three letter code
  • H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH
CAS registry number
  • 149635-73-4
Molecular Formula
  • C118H177N35O29S
Molecular Mass/ Weight
  • 2582.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse, rat

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Citations

Zinc transporter 3 (ZnT3) gene deletion reduces spinal cord white matter damage and motor deficits in a murine MOG-induced multiple sclerosis model

Neurobiol Dise . 2016 Oct 01 ; 94 205 | DOI : https://doi.org/10.1016/j.nbd.2016.06.018

  • BY. Choi

2′-5′ oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple sclerosis model

Neurosci Lett . 2016 Aug 15 ; 628 78 | DOI : https://doi.org/10.1016/j.neulet.2016.06.026

  • B. Choi

CCRL2 regulates M1/M2 polarization during EAE recovery phase

J Leukoc Biol . 2016 Jan 17 ; 99(6) 1027 | DOI : 10.1189/jlb.3MA0915-444RR

  • C. Mazzon

Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis

Am J Transl Res . 2016 Feb 15 ; 8(2) 1016 | DOI : PMC4846944

  • RA. Chandraratna

Altered Expression of Specific Transcription Factors of Th17 (RORγt, RORα) and Treg Lymphocytes (FOXP3) by Peripheral Blood Mononuclear Cells from Patients with Multiple Sclerosis

J Mol Neurosci. . 2016 Jul 02 ; 60(1) 94 | DOI : 10.1007/s12031-016-0789-5

  • Z. Etesam

Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis

Stem Cell Res Ther . 2016 Jan 04 ; 7 1 | DOI : 10.1186/s13287-015-0253-4

  • O. Trubiani

Transmembrane TNF–TNFR2 Impairs Th17 Differentiation by Promoting Il2 Expression

 J Immunol . 2015 Sep 15 ; 195(6) 2633 | DOI : https://doi.org/10.4049/jimmunol.1500286

  • PG. Miller

NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis in mice 

Intl immunol  . 2015 Jan 08 ; 27(5) 237 | DOI : https://doi.org/10.1093/intimm/dxu147

  • A. Maddell

Central Canal Ependymal Cells Proliferate Extensively in Response to Traumatic Spinal Cord Injury but Not Demyelinating Lesions

PLoS One . 2009 Dec 09 ; 9(1) e85916 | DOI : 10.1371/journal.pone.0085916

  • S. Lacroix

Effects of peptide fraction and counter ion on the development of clinical signs in experimental autoimmune encephalomyelitis  

J Neurochem . 2014 Jan 28 ; 129(4) 696 | DOI : https://doi.org/10.1111/jnc.12664

  • A. Boullerne

Dominant Effects of the Diet on the Microbiome and the Local and Systemic Immune Response in Mice

PLoS One . 2014 Jan 29 ; 9(1) e86366 | DOI : 10.1371/journal.pone.0086366

  • JH. Ooi

Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

 J Immunol . 2014 Jul 21 ; 204(2) 2438 | DOI : 10.4049/jimmunol.1400401

  • B. Aubé

CD98 is a potential target for ablating B cell clonal expansion and autoantibody in multiple sclerosis

 J Neuroimmunol . 2014 Sep 15 ; 274(1-2) 230 | DOI : https://doi.org/10.1016/j.jneuroim.2014.06.015

  • JM. Cantor

Sex‐specific control of central nervous system autoimmunity by p38 mitogen‐activated protein kinase signaling in myeloid cells

 Ann Neurol . 2013 Sep 11 ; 75(1) 50 | DOI : 10.1002/ana.24020

  • DN. Krementsov

The adaptor TRAF5 limits the differentiation of inflammatory CD4+ T cells by antagonizing signaling via the receptor for IL-6

 Nat Immunol . 2014 Mar 30 ; 15(5) 449 | DOI : 10.1038/ni.2863

  • H. Nagashima

Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling

Brain Behav Immun  . 2014 Aug 27 ; 40 61 | DOI : https://doi.org/10.1016/j.bbi.2014.02.003

  • S. Ouyang

Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway

 J Immunol . 2012 Sep 19 ; 189(9) 4417 | DOI : 10.4049/jimmunol.1200919

  • YG. Zhao

Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis

Brain . 2011 Feb 04 ; 134(Pt 3) 665 | DOI : 10.1093/brain/awq362

  • P. Polak

GH, but not GHRH, plays a role in the development of experimental autoimmune encephalomyelitis

Endocrinology . 2011 Aug 16 ; 152(10) 3803 | DOI : 10.1210/en.2011-1317

  • R. Shohreh

The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice

J Neuroimmunol . 2010 Sep 24 ; 229(1-2) 192 | DOI : 10.1016/j.jneuroim.2010.08.022

  • E. Aizman

Increasing CNS noradrenaline reduces EAE severity

J Neuroimmune Pharmacol  . 2009 Dec 04 ; 5(2) 252 | DOI : 10.1007/s11481-009-9182-2

  • MV. Simonini

Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins.

ASN Neuro . 2010 Jan 15 ; 2(1) e00025 | DOI : 10.1042/AN20090033

  • MV. Simonini

Dendritic cells transduced with lentiviral vectors expressing VIP differentiate into VIP-secreting tolerogenic-like DCs

Mol Ther  . 2010 Jan 12 ; 18(5) 1035 | DOI : 10.1038/mt.2009.293

  • MG. Toscano

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

Biochem Biophys Res Commun . 2009 May 09 ; 385(1) 49 | DOI : 10.1016/j.bbrc.2009.05.020

  • T. Kawasaki

Augmenting DAF levels in vivo ameliorates experimental autoimmune encephalomyelitis

Mol Immunol  . 2009 Aug 05 ; 46(15) 2885 | DOI : 10.1016/j.molimm.2009.07.003

  • Q. Li

The complement inhibitor FUT-175 suppresses T cell autoreactivity in experimental autoimmune encephalomyelitis

Am J Pathol . 2009 Jul 16 ; 175(2) 661 | DOI : 10.2353/ajpath.2009.081093

  • Q. Li

The type 1 IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

J Clin Invest  . 2008 May 01 ; 118(5) 1680 | DOI : 10.1172/JCI33342

  • B. Guo

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

J Neuroinflammation . 2008 Aug 08 ; 5 33 | DOI : 10.1186/1742-2094-5-33

  • AJ. Sharp

Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction

Exp Neurol. . 2015 Feb 20 ; 266 74 | DOI : 10.1016/j.expneurol.2015.02.018

  • DS. Barkauskas

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs

Cell Rep . 2018 Oct 30 ; 25(5) 1204 | DOI : https://doi.org/10.1016/j.celrep.2018.10.002

  • M. Fan

Contribution of LTi and TH17 cells to B cell aggregate formation in the central nervous system in a mouse model of multiple sclerosis

J Neuroinflammat . 2019 May 28 ; 16 111 | DOI : https://doi.org/10.1186/s12974-019-1500-x

  • V Schropp
  • et al

References

Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency

J Neuroimmunol  . 2007 Oct 26 ; 192(1-2) 124 | DOI : 10.1016/j.jneuroim.2007.09.024

  • RF. Frausto

Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis

J Neuroimmunol . 2003 Feb 01 ; 135(1-2) 117 | DOI : https://doi.org/10.1016/S0165-5728(02)00434-4

  • A. Kennel De March
  • et al

IgG Subclass Switching Is Associated with the Severity of Experimental Autoimmune Encephalomyelitis Induced with Myelin Oligodendrocyte Glycoprotein Peptide in NOD Mice

Cellular Immunol . 1999 Feb 01 ; 191(2) 97 | DOI : https://doi.org/10.1006/cimm.1998.1414

  • M. Ichikawa
  • et al

Induction of a Multiple Sclerosis-Like Disease in Mice with an Immunodominant Epitope of Myelin Oligodendrocyte Glycoprotein

Autoimmunity . 1997 Oct 29 ; 28(2) 109 | DOI : https://doi.org/10.3109/08916939809003872

  • A. Slavin
  • et al