DJ-1 (also known as PARK7, Parkinson disease protein 7) is a 189-amino acid protein that is ubiquitously expressed in many organs including brain, liver, kidney, pancreas, heart, and others.1-5 Although DJ-1 was originally discovered as a novel oncogene product, it was found to play several other roles in biological processes. These include regulation of RNA binding activity, fertility, anti-oxidative stress, and is linked to the early onset of Parkinson disease when mutated.1-5 Recently, it was demonstrated that DJ-1 can act as an atypical peroxiredoxin-like peroxidase5 and possesses protease activity.4
1. Huai, Q. et al. FEBS Letters 549, 171 (2003).
2. Inden, M. et al. J Pharma Sci 117, 189 (2011).
3. Kitamura, Y. et al. Mol Neurodegener 6, 1 (2011).
4. Chen, J. et al. Hum Mol Genetics 19, 2395 (2010).
5. Andres-Mateos, E., et al. Proc Nat Acad Sci 104, 14807 (2007).