Tau & Beta Amyloid Peptides
Tau and Beta Amyloid>



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Beta Amyloid Peptides

Beta-Amyloid (A▀) peptides assemble into long, insoluble ordered fibers and are deposited extracellularly in tissue amyloidosis. These peptides are generated as cleavage products 39 to 43 amino acids in length from the membrane protein, Amyloid Precursor Protein (APP) by two proteases, ▀-secretase and γ-secretase. A▀s are amphiphilic peptides with a hydrophilic N-terminal domain (residues 1 to 28) and a hydrophobic C-terminal (residues 29 to 40), the latter corresponding to a part of the transmembrane domain of APP.

Tau Peptides & Tau Proteins

TAU proteins belong to the microtubule-associated protein (MAP) family and are involved in the pathogenesis of Alzheimer's disease. In the human brain, there are six TAU isoforms ranging from 352 to 441 amino acids in length. These isoforms vary at the carboxyl terminal according to the presence of either three repeat (3R) or four repeat (R4) domains, in addition to the presence or absence of one or two insert domains at the amino-terminus.
Item Catalog Number Size
Tau Peptide (45 - 73) (Exon 2/Insert 1 domain)
ESPLQTPTEDGSEEPGSETSDAKSTPTAE
AS-65431-1
1 mg
Tau Peptide (244 - 274) (Repeat 1 domain)
Ac-QTAPVPMPDLKNVKSKIGSTENLKHQPGGGK
AS-65433-1
1 mg
Tau Peptide (275 - 305) (Repeat 2 domain)
VQIINKKLDLSNVQSKCGSKDNIKHVPGGGS
AS-65434-1


1 mg
Recombinant Human Tau (Tau - 441) Protein AS-55556-50
AS-55556-100

50 ug
100 ug

Recombinant Human Tau (Tau - 441) Protein, GST tagged AS-55557-50
AS-55557-100
50 ug
100 ug

Assay Kits

AnaSpec is committed to providing tools to facilitate the advancement of Alzheimer's disease research. These tools include our FRET-based SensoLyte« 520 assay kits for the detection of amyloid degrading enzymes such as β-Secretase, BACE2, ADAM 10 or Neprilysin.
Item

MORE RELATED PRODUCTS for AD Research

Dyes
Congo Red
, Thioflavin T and their derivatives for labeling amyloid fibrils

Antibodies
Tau Antibodies - phospho and non-phospho specific
Anti-Tau Antibody (GlcNAc Ser400) & Anti-Tau Antibody (Ser400)


References:
TAU
1. Goedert, M. et al. Neuron, 3, 519 (1989).
2. Evans, DB. et al. JBC 275, 24977 (2000).
3. Luc, B. et al. Brain Res Rev 33, 95 (2000).
4. Arai, T. et al. JBC 280, 5145 (2005).
5. Yuzwa, SA. et al. Amino Acid 40, 857 (2011).
6. Irwin, D. et al. Brain 135, 807 (2012).
7. Cohen, T. et al. Nat Commun 2, 252 (2011).
8. Eckermann, K. et al. J Biol Chem 282, 31755 (2007).
9. Mocanu, M. et al. J Neurosci 28, 737 (2008).
Beta Amyloid
1. Selkoe DJ. Nature 399, A23 (1999).
2. Suh, Y-H. and F. Checler, Pharmacol Rev 54, 469 (2002).
3. Kang, J. et al. Nature 325, 733 (1987).
4. Jarrett, JT. et al. Biochem 32, 4693 (1993).
5. Masters, CL. et al. EMBO J 4, 2757 (1985).
6. Braak, H. et al. Acta Neuropathol 87, 554 (1994).
7. Nagele, R. et al. Neurosci 110, 199 (2002).
8. Garzon-Rodriguez, W. et al. J Biol Chem 272, 21037 (1997).