NEW Labeled Antibodies: Anti-CD-3ε, Anti-CD79α


Leveraging our expertise in antibody production, AnaSpec is pleased to offer our anti-CD-3ε and anti-CD79a antibodies. These quality antibodies can be custom labeled with classic labels such as biotin, FAM, and FITC as well as AnaSpec's proprietary HiLyte™ Fluor labels.

Custom labeling service for all our primary antibodies is available. Available labels include HiLyte™ Fluor™ dyes, HRP, AP, biotin, R-PE (R-phycoerythrin) and B-PE (B-phycoerythrin). Please inquire at service@anaspec.com

Anti-CD-3ε

T cell activation through the T cell antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3g, CD3d, CD3e and CD3z.1,2 These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11.1 The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3e may play a role in TCR-induced growth arrest, cell survival and proliferation.3 Rabbit anti-CD3e polyclonal antibody was raised against a synthetic peptide from the human CD3 protein, epsilon chain, only one amino acid different from mouse and rat origins.

Cat#

Form

Unit Size

29588

Unconjugated

50 mg








IHC of Human tonsil probed with anti-CD3ε (Cat# 29588).
Anti-CD-79α

The CD79 molecule, comprising two polypeptide chains, mb-1 (CD79α) and B29 (CD79β), is physically associated in the B-cell membrane with immunoglobulins to constitute the B cell antigen receptor (BCR).4,5 The CD79α/β heterodimer interacts with at least one tyrosine kinase (Lyn).6 Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79α/β dimer, and also of other molecules, thereby initiating intracellular signaling.6 Almost all acute lymphoblastic leukemias of precursor B cell type are positive when tested with CD79α antibodies.7-9 Rabbit anti-CD79α polyclonal antibody was raised against a synthetic peptide corresponding to human and mouse CD79α.






IHC of Human tonsil probed with anti-CD79α(Cat# 29560).


Cat#

Form

Unit Size

29560

Unconjugated

50 mg

Custom Labeling Service Available for the following:

Label

Abs/Em

AP

N/A

HRP

N/A

Biotin

N/A

AMCA

353/442

FAM

492/518

FITC

493/517

TAMRA

542/568

HiLyte™ 488

498/525

HiLyte™ 555

552/569

HiLyte™ 647

649/674

HiLyte™ 750

753/778

R-PE

565/575

B-PE

545/575

Related Products:

AnaTag Labeling Kits

References:

1. Clevers, H. et al. Annu. Rev. Immunol. 6, 629(1988).
2. Malissen, B. et al. Curr. Opin. Immunol. 5, 324 (1993).
3. Gil, D. et al. J. Biol. Chem. 276, 11174 (2001).
4. Mason, DY. et al. Blood 86, 1453 (1995).
5. Payelle-Brogard, B. et al. Blood 94, 3516 (1999).
6. Chu, PG. et al. Appl. Immunohistochem. Mol. Morphol. 9, 97 (2001).
7. Verschuren, MCM. et al. Leukemia 7, 1931 (1993).
8. Buccheri, V. et al. Blood 82, 853 (1993).
9. Payelle-Brogard, et al. Br. J. Hematology 118, 976 (2002).