we feature an important family of proteins called Bcl-2 (B-cell lymphoma 2)
for use in cancer research or cell cycle research. These important regulators
of apoptosis have been implicated in a number of neoplasms, including melanoma,
breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity.
family is comprised of more than 20 members, divided
into 3 subfamilies. Depending on Bcl-2 subcellular localization, it
can inhibit (anti-apoptotic members) or induce (pro-apoptotic members) apoptosis.
subfamily (pro-apoptotic): Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A1
2. Bax subfamily (pro-apoptotic): Bax, Bak and Bok
3. BH3 subfamily (pro-apoptotic): Bad, Bid, Bik, Blk, Hrk, BNIP3 and
Figure 1. Domain structure of Bcl-2
family proteins. [from Gustafsson, ÅB. and RA. Gottlieb, Am J Physiol
Cell Physiol 292, C45 ( 2007)].
Cory, S. and JM. Adams, Nature
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(2003); Internet, http://www.celldeath.de/encyclo/misc/bcl2.htm,
Oct. 24, 2007.