Bcl Peptides - Wide Selection


This month we feature an important family of proteins called Bcl-2 (B-cell lymphoma 2) for use in cancer research or cell cycle research. These important regulators of apoptosis have been implicated in a number of neoplasms, including melanoma, breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity.

The Bcl-2 family is comprised of more than 20 members, divided into 3 subfamilies. Depending on Bcl-2 subcellular localization, it can inhibit (anti-apoptotic members) or induce (pro-apoptotic members) apoptosis.

Bcl-2 Subfamilies:

1.         Bcl-2 subfamily (pro-apoptotic): Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A1
2. Bax subfamily (pro-apoptotic): Bax, Bak and Bok
3. BH3 subfamily (pro-apoptotic): Bad, Bid, Bik, Blk, Hrk, BNIP3 and BimL


Figure 1. Domain structure of Bcl-2 family proteins. [from Gustafsson, ÅB. and RA. Gottlieb, Am J Physiol Cell Physiol 292, C45 ( 2007)].

Product

Size

Catalog #

Bcl-2 LSPVPPVVHLALRQAGDDFSRRYRG

1 mg

62273

Bax BH3 peptide (55-74); wild type
STKKLSECLKRIGDELDSNM

1 mg

62266

[Glu63] Bax BH3; mutant
STKKLSECEKRIGDELDSNM

1 mg

62267

Bax-BH3
KKLSECLKRIGDELDS

1 mg

61629

Bax-BH3L63A
KKLSECAKRIGDELDS

1 mg

61630

Bak BH3; Bcl2 (72-87)
KGGGQVGRQLAIIGDDINR

1 mg

62235

Bak-BH3 peptide; Mca labeled
Mca-GQVGRQLAIIGDDINR, Abs/Em=325/393 nm

1 mg

62029

Bak-BH3; TAMRA-labeled
GQVGRQLAIIGDDINR-K(TAMRA)-NH2, Abs/Em=544/572 nm

0.5 mg

62030

Bak-BH3
RNIARHLAQVGDSMDR

1 mg

61616

BAD (103-127); human
NLWAAQRYGRELRRMSDEFVDSFKK

1 mg

60984

BAD (103-126); human
NLWAAQRYGRELRRMSDEFVDSFK

1 mg

60983

BAD (103-127); human; FAM-labeled
FAM-NLWAAQRYGRELRRMSDEFVDSFKK, Abs/Em=494/521 nm

0.5 mg

60985

Bid BH3; FAM labeled
5-FAM-EDIIRNIARHLAQVGDSMDR, Abs/Em=494/521 nm

0.5 mg

61712

Bid BH3 Peptide
EDIIRNIARHLAQVGDSMDR

1 mg

61711

Bid BH3-r8
rrrrrrrr-GEDIIRNIARHLAQVGDSMDR

0.5 mg

61715

Bid BH3-R8
RRRRRRRR-GEDIIRNIARHLAQVGDSMDR

1 mg

62057

Bid BH3-R9
RRRRRRRRR-GEDIIRNIARHLAQVGDSMDR

1 mg

61713

[A90;95] Bid BH3 (77-100); mouse
ESQEEIIHNIARHAAQIGAEMDHN

1 mg

62318

Bid-BH3
RNIARHLAQVGDSMDR

1 mg

61631

Bim-23056
fFYwKVFnal-NH2

1 mg

62263

BMf-BH3
LQHRAEVQIARKLQCIADQFHRLHT

1 mg

62281

Noxa BH3; Peptide 1 NEW
PAELEVECATQLRRFGDKLNFRQKLL

1 mg

62282

Related Products

Product

Size

Catalog #

Anti-Bad NEW
Bcl-2 antagonist of cell death; Bcl-2-like 8; Bcl-2 binding component 6

50 g

54178

Anti-Bim (IN) NEW
Bcl-2 interacting protein; Bcl-2-related ovarian death gene; BOD; Bcl-2-like 11

50 g

54013

Anti-Bcl-rambo (IN) NEW
Bcl-2 like protein 13; Mil1

50 g

54118

Anti-Bak (NT) NEW
Bcl-2 antagonist/killer; Bcl-2-like 7 protein

50 g

53251

Anti-Bit1 (IN) NEW
Bcl-2 inhibitor of transcription 1; Peptidyl-tRNA hydrolase 2

50 g

54225

Anti-Bit1 (NT) NEW
Bcl-2 inhibitor of transcription 1; Peptidyl-tRNA hydrolase 2

50 g

54224

Anti-Bax (NT) NEW
Bcl-2 associated protein X

50 g

54179

Anti-Bmf (CT) NEW
Bcl-2 modifying factor

50 g

54121

Anti-Bmf (NT) NEW
Bcl-2 modifying factor

50 g

54122

Anti-PUMA (NT) NEW
p53 upregulated modulator of apoptosis; bbc3; Bcl-2 binding component 4

50 g

54020

Anti-PUMA (CT) NEW
p53 upregulated modulator of apoptosis; bbc3; Bcl-2 binding component 3

50 g

54019

Anti-Bim (Bod) (IN2) NEW
Bod; Bcl-2 like 11

50 g

54191

Anti-Bcl-2 (IN) NEW
B-cell/CLL lymphoma protein 2

50 g

54176

Anti-Bcl-2 (NT) NEW
B-cell/CLL lymphoma protein 2

50 g

54175

Anti-Bcl-xL NEW
Bcl-2-like protein

50 g

54177

Anti-Bcl-G (CT) NEW
Bcl-2-like 14

50 g

54143

Anti-Bcl-B / Bcl-2L10 / Boo / Diva / Nrh NEW
Bcl-2L10; Boo; Diva; Nrh

50 g

54142

Anti-Bcl-2 (pThr129) NEW

50 g

29658

Anti-Bcl-10 (NT) NEW
CIPER; mE10; CARMEN; CLAP

50 g

54052

Anti-SODD (NT) NEW
Silencer of death domains; Bcl-2-associated athanogene 4; BAG-4

50 g

54047

Anti-Bik / apoptosis inducer NBK NEW
Bcl-2-interacting killer; apoptosis inducer NBK

50 g

54267

Anti-Bfl-1 (CT) NEW
Bcl-2-related protein A1; Hemopoietic-specific early response protein

50 g

54276

Anti-Beclin-1 (NT) NEW
Coiled-coil myosin-like Bcl-2-interacting protein

50 g

54229

Anti-Bfl-1 (NT) NEW
Bcl-2-related protein A1; Hemopoietic-specific early response protein

50 g

54277

Anti-BAG-1 / RAP46 (CT) NEW
Bcl-2-binding athanogene-1; receptor-associated protein 46; RAP46

50 g

54274

Anti-Beclin-1 (CT) NEW
Coiled-coil myosin-like Bcl-2-interacting protein

50 g

54228

Anti-BAG-1 / RAP46 (NT) NEW
Bcl-2-binding athanogene-1; receptor-associated protein 46; RAP46

50 g

54275

Anti-BAG-1 NEW
Bcl-2-Binding Athanogene-1

50 g

53250

References:

Cory, S. and JM. Adams, Nature Reviews 2, 647 (2002); Portier, B. and G.Taglialatela J. Biol. Chem. 281, 40493 (2006); Massaad, C. et al. J. Biol. Chem. 279, 54470 (2004); Denis, G. et al. J. Biol. Chem. 278, 5775 (2003); Internet, http://www.celldeath.de/encyclo/misc/bcl2.htm, Oct. 24, 2007.