Channel Blocker Peptides


With one of the world's largest collections of peptides, AnaSpec continues to expand its selection with a selection of channel blocker peptides.

Peptide toxins are potent and selective compounds that can act on ion channels in plasma membrane of excitable cells.1  These high specificity and affinity compounds, often with diverse and selective pharmacologies, are used as pharmacological probes to study and characterize various receptor proteins involved in ion-channel function.1 These toxin peptides generally consist of a relatively small number of structural frameworks that are particularly suited to addressing the crucial issues of potency and stability.1 Multiple disulfide bonds constitute essential structural elements in many of these bioactive peptides, which are generated by proteolytic processing of prefolded protein precursors and then released from the cells in the bioactive form into the extracellular medium to exert their physiological function.

Ca2+ Channel Blockers

Peptide Name

Source

Sequence

Disulfide Bridge

Channel Type/Action of class

Size (mg)

Catalog#

ω-Conotoxin GVIA

Marine snail,

Conus geographus

CKS(Hyp)GSSCS(Hyp)
TSYNCCRSCN(Hyp)
YTKRCY-NH2

C1-C16, C8-C19, C15-C26

N-type. Binds Neuronal Ca2+ channels. Blocks synapse neurotransmitter release reversibly.

0.5

1

22926

22927

K+ Channel Blockers

Iberiotoxin (IbTX)

Scorpion,

Buthus tamulus

Pyr-FTDVDCSVS

KECWSVCKDLFGVDR
GKCMGKKCRCYQ

C7-C28, C13-C33, C17-C35

BK type 1 ; Ca2+, K channel inhibitor

0.1

60763

Charybdotoxin

Scorpion, Leiurus quinquestriatus hebraeus

Pyr-FTNVSCTTS

KECWSVCQRLHNTSR
GKCMNKKCRCYS

C7-C28, C13-C33, C17-C35

Ca2+activated K+channel blocker

0.1

 

28244

 

Apamin

Bee

CNCKAPETALCARRCQQH-NH2

C1-C11,

C3-C15

Ca2+ dependent K+ channel blocker, SK blocker

0.5

60772

Cl-Channel Blocker

Chlorotoxin (Cltx)

Scorpion,

Leiurus quinquestriatus

MCMPCFTTDHQMARKCDDCCGGKGA
GKCYGPQCLCR-NH2

C2-C19, C5-C28, C16-C33, C20-C35

Cl- channel blocker

0.1

60770

Other Ion Channel Blockers

Conantokin G

Fish eating snail,

Conus geographus

GE(Gla)(Gla)LQ(Gla)NQ
(Gla)LIR(Gla)KSN-NH2

 

NMDA receptor glutamate antagonist

0.5

 

24281

 

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Reference:

1.  Lewis, RJ. and ML. Garcia, Nat. Rev. Drug Discov. 2, 790 (2003).