LL-37 peptides are AnaSpec's latest addition to our expansive collection
of research-ready, on-demand GO™ Peptides. The LL-37 GO™ collection
includes LL-37 fragments consisting of 18-37; FAM, biotin-LC-labeled
LL-37 (LC is a 6-carbon linker); and Cys-LC-LL-37 - useful in applications such
as conjugation to resin. Sepharose linked LL-37 is available as a custom order.
New antimicrobial peptides (AMP) include Dermcidin, DCD-1L.
Cathelicidins are cationic peptides that have broad-range antimicrobial activity.1
These peptides belong to the family of anti-microbial peptides which form part
of the host's important innate immunity mechanism.2 In humans, cathelicidins
and defensins are expressed in immune cells and at epithelial surfaces.3-5 hCAP18,
human cationic antimicrobial protein, with a MW of 18 kD, is the only cathelicidin
gene found in humans.2 The N-terminus of this protein consists of a cathelin-like
region (highly conserved among species) and a C-terminal termed LL-37.6-7 An amphipathic
alpha-helical peptide, LL-37 plays an important role in the first line of defense
against local infection and systemic invasion of pathogens at sites of inflammation
and wounds. Cytotoxic to both bacterial and normal eukaryotic cells, LL-37 is
significantly resistant to proteolytic degradation in solution.8-9 In addition
to having antimicrobial activity, LL-37 has been shown to play a role in chemoattraction,
dendritic cell differentiation, mast cell degranulation, cytokine secretion, angiogenesis
stimulation, and wound healing.10 In other species, the C-terminal antimicrobial
region varies in sizes, sequences and structures. 10
for more information.
To view our complete list of anti-microbial peptides (AMPs), please click here.
· SensoLyte Cathepsin
D Assay Kits
· SensoLyte Cathepsin S Assay Kits
· DHL Cell Cytotoxicity
1. Zanetti, M. et al. J.
Biol. Chem. 268, 522 (1993).
2. Lehrer, R. and T. Ganz. Curr. Opin. Immunol. 11, 23
3. Ganz, T. Nat. Rev. Immunol. 3, 710 (2003).
4. Zanetti, M. J. Leukoc. Biol. 75, 39 (2004).
5. Chromek, M. et al. Nature Medicine 12, 636
6. Zanetti, M. et al. FEBS Lett. 374, 1 (1995).
7. Sorensen, OE. et al. Blood 97,
8. Neville, F. et al. Biophys. J. 90, 1275 (2006)
9. Oren, Z., et al. Biochem. J. 341,
10. Gordon, YJ. et al. Curr. Eye Res. 30, 385 (2005).