OVA (SIINFEKL) Peptides & Variants are GO™


Proteolytic processing of proteins in the cytoplasm generates peptide epitopes that are generally 8-10 amino acids in length. The binding of these peptides to the surface major histocompatibility complex (MHC) class I molecules and subsequent presentation to T-cells elicits an immune response.1 A model antigen extensively studied is Ovalbumin (OVA). OVA is processed to the presenting octapeptide (257-264), SIINFEKL, through proteasomal and non-proteasomal activities.2 As with peptides naturally presented by H-2Kb, SIINFEKL has on its 5th position an amino acid with an aromatic side chain (Phe) and on the 8th position, an aliphatic side chain (Leu).3 Variants of this peptide consisting of substituting different amino acids at strategic positions have yielded valuable information on the interaction of this peptide and the MHC complex.3

The use of AnaSpec's SIINFEKL has been reported in peer-reviewed journals since 1997. We are pleased that researchers have trusted us to provide this important peptide. We are also pleased to announce the recent release of variants of this peptide.

Product

Sequence Size

Catalog #

OVA (257 - 264)

SIINFEKL

1 mg

5 mg

60193-1

60193-5

OVA (257 - 264), amide

SIINFEKL - NH2

5 mg

62572-5

OVA (257 - 264), scrambled

FILKSINE

1 mg

64413

OVA - A2 Peptide, OVA (257 - 264) Variant NEW

SAINFEKL

1 mg

64383

OVA - G4 Peptide, OVA (257 - 264) Variant NEW

SIIGFEKL

1 mg

64384

OVA - Q4 Peptide, OVA (257 - 264) Variant NEW

SIIQFEKL

1 mg

64402

OVA - T4 Peptide, OVA (257 - 264) Variant NEW

SIITFEKL

1 mg

64403

OVA - Q4H7 Peptide, OVA (257 - 264) Variant NEW

SIIQFEHL

1 mg

64405


Related OVA Peptides

Product

Sequence

Size

Catalog #

OVA (323 - 339)

ISQAVHAAHAEINEAGR

1 mg

5 mg

27024

27025

OVA (323 - 339), amide

ISQAVHAAHAEINEAGR - NH2

1 mg

5 mg

62571-1

62571-5

HSV - gB2 (498 – 505)

SSIEFARL

1 mg

61708

Related Products

Anti-CD antibodies

References:

  1. Heemel, M & H. Ploegh Annu. Rev. Biochem. 64, 463 (1995).
  2. Beninga, J. et al. J. Biol. Chem. 273, 18734 (1998).
  3. Hin, S. et al. J. Biol. Chem. 276, 48790 (2001).