Histone H3 Peptides are GO™


Chromatin exist either as the transcriptionally active euchromatin or as the transcriptionally repressed heterchromatin state.1 Post-translational modifications of histone "tails" (amino termini) have been implicated in the conversion between the two states. 1-2 Covalent modifications, such as acetylation, methylation and phosphorylation affect chromatin structure and exquisitely regulate gene expression.3-6 Histone hyperacetylation is correlated with increased transcription, whereas hypoacetylation correlates with transcriptional repression.5 In Histone H3, preferential methylation sites have been shown to be Lys-4, Lys-9, Lys-27 and Lys-36, with methylation generally leading to transcriptional suppression.3,7 Phosphorylation at Ser10 (pSer10) is implicated in both transcription and cell division.8

AnaSpec, the world's largest provider of on-demand GO™ peptides is pleased to announce the rapid expansion of our histone H3 peptide selection. These new Histone H3 GO™ Peptides include sequences that are acetylated, mono-, di- or tri-methylated, phosphorylated and biotinylated.

Product

Size

Catalog #

[Lys(Me1)4] - Histone H3 (1 - 10), H3K4(Me1)
ART - K(Me1) - QTARKS

1 mg

AS-64369-1

[Lys(Me2)4] - Histone H3 (1 - 10), H3K4(Me2)
ART - K(Me2) - QTARKS

1 mg

AS-64370-1

[Lys(Me3)4] - Histone H3 (1 - 10), H3K4(Me3)
ART - K(Me3) - QTARKS

1 mg

AS-64371-1




Product

Size

Catalog #

[Lys(Ac)14] - Histone H3 (1 - 19), H3K14(Ac)
ARTKQTARKSTGG - K(Ac) - APRKQ

1 mg

AS-63682

Histone H3 (1 - 20), N - Terminal
ARTKQTARKSTGGKAPRKQL

1 mg

AS-62753

[Lys(Ac)9] - Histone H3 (1 - 20), H3K9(Ac)
ARTKQTAR - K(Ac) - STGGKAPRKQL

1 mg

AS-63680

Histone H3 (1 - 21), FAM labeled
ARTKQTARKSTGGKAPRKQLAGG - K(FAM) - NH2

1 mg

AS-63824

Histone H3 (1 - 21), N - Terminal
ARTKQTARKSTGGKAPRKQLA

1 mg

AS-61701

[Lys(Me2)4] - Histone H3 (1 - 21), H3K4(Me2)
ART - K(Me2) - QTARKSTGGKAPRKQLA

1 mg

AS-63677

Histone H3 (1 - 21), K4 di - methylated, H3K4(Me2), FAM labeled
ART - K(Me2) - QTARKSTGGKAPRKQLAGG - K(FAM) - NH2

1 mg

AS-63825

[Lys(Ac)9] - Histone H3 (1 - 21), H3K9(Ac)
ARTKQTAR - K(Ac) -STGGKAPRKQLA

1 mg

AS-64191

Histone H3 (1 - 25), amide
ARTKQTARKSTGGKAPRKQLATKAA - NH2

1 mg

AS-61703

[Lys(Me3)9] - Histone H3 (3 - 17), H3K9(Me3)
TKQTAR - K(Me3) - STGGKAPR

1 mg

AS-64374-1

[Lys(Ac)14] - Histone H3 (9 - 19), H3K14(Ac)
KSTGG - K(Ac) - APRKQ

1 mg

AS-63681




Product

Size

Catalog #

[Lys(Me1)9] - Histone H3 (3 - 17), H3K9(Me1)
TKQTAR - K(Me1) - STGGKAPR

1 mg

AS-64372-1

[Lys(Me2)9] - Histone H3 (3 - 17), H3K9(Me2)
TKQTAR - K(Me2) - STGGKAPR

1 mg

AS-64373-1

[Lys(Me3)9] - Histone H3 (3 - 17), H3K9(Me3)
TKQTAR - K(Me3) - STGGKAPR

1 mg

AS-64374-1




Product

Size

Catalog #

Histone H3 (23 - 34)
KAARKSAPATGG

1 mg

AS-64375-1

[Lys(Me1)27] - Histone H3 (23 - 34), H3K27(Me1)
KAAR - K(Me1) - SAPATGG

1 mg

AS-64376-1

[Lys(Me2)27] - Histone H3 (23 - 34), H3K27(Me2)
KAAR - K(Me2) - SAPATGG

1 mg

AS-64377-1

[Lys(Me3)27] - Histone H3 (23 - 34), H3K27(Me3)
KAAR - K(Me3) - SAPATGG

1 mg

AS-64378-1




Product

Size

Catalog #

[Lys(Me1)36] - Histone H3 (31 - 41), H3K36(Me1)
STGGV - K(Me1) - KPHRY

1 mg

AS-64379-1

[Lys(Me2)36] - Histone H3 (31 - 41), H3K36(Me2)
STGGV - K(Me2) - KPHRY

1 mg

AS-64380-1

[Lys(Me3)36] - Histone H3 (31 - 41), H3K36(Me3)
STGGV - K(Me3) - KPHRY

1 mg

AS-64381-1




Product

Size

Catalog #

Histone H3 (1 - 21), biotin-labeled
ARTKQTARKSTGGKAPRKQLA - GGK(Biotin) - NH2

1 mg

AS-61702

[Lys(Me1)4] - Histone H3 (1 - 21) - GGK(Biotin), H3K4(Me1), biotin - labeled
ART - K(Me1) - QTARKSTGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

AS-64355-025

AS-64355-1

[Lys(Me2)4] - Histone H3 (1 - 21) - GGK(Biotin), H3K4(Me2), biotin - labeled
ART - K(Me2) - QTARKSTGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

AS-64356-025

AS-64356-1

[Lys(Me3)4] - Histone H3 (1 - 21) - GGK(Biotin), H3K4(Me3), biotin - labeled
ART - K(Me3) - QTARKSTGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

AS-64357-025

AS-64357-1




Product

Size

Catalog #

[Lys(Me1)9] - Histone H3 (1 - 21) - GGK(Biotin), H3K9(Me1), biotin - labeled
ARTKQTAR - K(Me1) - STGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

AS-64358-025

AS-64358-1

[Lys(Me2)9] - Histone H3 (1 - 21) - GGK(Biotin), H3K9(Me2), biotin - labeled
ARTKQTAR - K(Me2) - STGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

AS-64359-025

AS-64359-1

[Lys(Me3)9] - Histone H3 (1 - 21) - GGK(Biotin), H3K9(Me3), biotin - labeled
ARTKQTAR - K(Me3) - STGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

AS-64360-025

AS-64360-1

[Lys(Me2)9] - Histone H3 (1 - 21) - K(Biotin), H3K9(Me2), biotin labeled
ARTKQTAR - K(Me2) - STGGKAPRKQLA - K(Biotin)

1 mg

AS-63678




Product

Size

Catalog #

Histone H3 (21 - 44) - GK(Biotin), H3K27, biotin – labeled
ATKAARKSAPATGGVKKPHRYRPG-GK(Biotin)

0.25 mg

1 mg

AS-64440-025

AS-64440-1

[Lys(Me1)27] - Histone H3 (21 - 44) - GK(Biotin), H3K27(Me1), biotin - labeled
ATKAAR - K(Me1) - SAPATGGVKKPHRYRPG - GK(Biotin)

0.25 mg

1 mg

AS-64365-025

AS-64365-1

[Lys(Me2)27] - Histone H3 (21 - 44) - GK(Biotin), H3K27(Me2), biotin - labeled
ATKAAR - K(Me2) - SAPATGGVKKPHRYRPG - GK(Biotin)

0.25 mg

1 mg

AS-64366-025

AS-64366-1

[Lys(Me3)27] - Histone H3 (21 - 44) - GK(Biotin), H3K27(Me3), biotin - labeled
ATKAAR - K(Me3) - SAPATGGVKKPHRYRPG - GK(Biotin)

0.25 mg

1 mg

AS-64367-025

AS-64367-1




Product

Size

Catalog #

Histone H3 (21 - 44) - GK(Biotin), H3K27, biotin – labeled NEW
ATKAARKSAPATGGVKKPHRYRPG-GK(Biotin)

0.25 mg

1 mg

AS-64440-025

AS-64440-1

[Lys(Me1)36] - Histone H3 (21 - 44) - GK(Biotin), H3K36(Me1), biotin - labeled
ATKAARKSAPATGGV - K(Me1) - KPHRYRPG - GK(Biotin)

0.25 mg

1 mg

AS-64368-025

AS-64368-1

[Lys(Me2)36] - Histone H3 (21 - 44) - GK(Biotin), H3K36(Me2), biotin - labeled
ATKAARKSAPATGGV - K(Me2) - KPHRYRPG - GK(Biotin)

0.25 mg

1 mg

AS-64442-025

AS-64442-1

[Lys(Me3)36] - Histone H3 (21 - 44) - GK(Biotin), H3K36(Me3), biotin - labeled
ATKAARKSAPATGGV - K(Me3) - KPHRYRPG - GK(Biotin)

0.25 mg

1 mg

AS-64441-025

AS-64441-1




Product

Size

Catalog #

[Lys(Ac)9] - Histone H3 (1 - 21) - GGK(Biotin), H3K9(Ac), biotin - labeled
ARTKQTAR - K(Ac) - STGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

AS-64361-025

AS-64361-1

[Lys(Ac)9] - Histone H3 (1 - 21) - NH2, H3K9(Ac), biotin - labeled, amide
ARTKQTAR - K(Ac) - STGGKAPRKQLA - GGK(Biotin) - NH2

1 mg

AS-64190

[Lys(Ac)14] - Histone H3 (1 - 21) - GGK(Biotin), H3K14(Ac), biotin - labeled
ARTKQTARKSTGG - K(Ac) - APRKQLA - GGK(Biotin)

0.25 mg

1 mg

AS-64362-025

AS-64362-1

[Lys(Ac)9/14] - Histone H3 (1 - 21) - GGK(Biotin), H3K9/14(Ac), biotin - labeled
ARTKQTAR - K(Ac) - STGG - K(Ac) - APRKQLA - GGK(Biotin)

0.25 mg

1 mg

AS-64363-025

AS-64363-1

[pSer10), Lys(Ac)14] - Histone H3 (1 - 21) - GGK(Biotin), biotin - labeled
ARTKQTARK - pS - TGG - K(Ac) - APRKQLAGGK(Biotin)

0.25 mg

 

AS-64364-025

 

Related Products

Histone H1 Peptides

Histone H2A Peptides

Histone H4 Peptides

Histone Related Substrates

AnaSpec is the sole provider of the industry's long wavelength HDAC assay kit, the SensoLyte 520 HDAC Activity Assay Kit. We also provide unusual amino acid building blocks such as Lys(Ac), Lys(Me1-3), Arg(Me2) for histone peptide synthesis.

References:

1. Grunstein, M. et al. J. Cell Sci. Suppl. 19, 29 (1995).
2. Strahl, BR and CD Allis, Nature 403, 41 (2000).
3. Strahl, BD. et al. Proc. Natl. Acad. Sci. 96, 14967 (1999).
4. Jenuwein, T. and CD. Allis Science 293, 1074 (2001).
5. Sterner, DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
6. Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).
7. Nishioka, K. et al. Genes & Dev. 16, 479 (2002).
8. Prigent, C. and S. Dimitrov, J. Cell Sci. 116, 3677 (2003).