Histone H3 Peptides are GO™


Chromatin exist either as the transcriptionally active euchromatin or as the transcriptionally repressed heterchromatin state.1 Post-translational modifications of histone “tails” (amino termini) have been implicated in the conversion between the two states. 1-2 Covalent modifications, such as acetylation, methylation and phosphorylation affect chromatin structure and exquisitely regulate gene expression.3-6 Histone hyperacetylation is correlated with increased transcription, whereas hypoacetylation correlates with transcriptional repression.5 In Histone H3, preferential methylation sites have been shown to be Lys-4, Lys-9, Lys-27 and Lys-36, with methylation generally leading to transcriptional suppression.3,7 Phosphorylation at Ser10 (pSer10) is implicated in both transcription and cell division.8

AnaSpec, the world’s largest provider of on-demand GO™ peptides is pleased to announce the rapid expansion of our histone H3 peptide selection. These new Histone H3 GO™ Peptides include sequences that are acetylated, mono-, di- or tri-methylated, phosphorylated and biotinylated.

Product

Size

Catalog #

[Lys(Me1)4] - Histone H3 (1 - 10), H3K4(Me1) NEW
ART - K(Me1) - QTARKS

1 mg

64369-1

[Lys(Me2)4] - Histone H3 (1 - 10), H3K4(Me2) NEW
ART - K(Me2) - QTARKS

1 mg

64370-1

[Lys(Me3)4] - Histone H3 (1 - 10), H3K4(Me3) NEW
ART - K(Me3) - QTARKS

1 mg

64371-1




Product

Size

Catalog #

[Lys(Ac)14] - Histone H3 (1 - 19), H3K14(Ac)
ARTKQTARKSTGG - K(Ac) - APRKQ

1 mg

63682

Histone H3 (1 - 20), N - Terminal
ARTKQTARKSTGGKAPRKQL

1 mg

62753

[Lys(Ac)9] - Histone H3 (1 - 20), H3K9(Ac)
ARTKQTAR - K(Ac) - STGGKAPRKQL

1 mg

63680

Histone H3 (1 - 21), FAM labeled NEW
ARTKQTARKSTGGKAPRKQLAGG - K(FAM) - NH2

1 mg

63824

Histone H3 (1 - 21), N - Terminal
ARTKQTARKSTGGKAPRKQLA

1 mg

61701

Histone H3 (1 - 21) - Cys NEW
ARTKQTARKSTGGKAPRKQLAC

1 mg

63789

[Lys(Me2)4] - Histone H3 (1 - 21), H3K4(Me2)
ART - K(Me2) - QTARKSTGGKAPRKQLA

1 mg

63677

Histone H3 (1 - 21), K4 di - methylated, H3K4(Me2), FAM labeled NEW
ART - K(Me2) - QTARKSTGGKAPRKQLAGG - K(FAM) - NH2

1 mg

63825

[Lys(Ac)9] - Histone H3 (1 - 21), H3K9(Ac)
ARTKQTAR - K(Ac) -STGGKAPRKQLA

1 mg

64191

[Lys(Me3)9] - Histone H3 (1 - 24), H3K9(Me3)
ARTKQTAR - K(Me3) - STGGKAPRKQLATKA

0.5 mg

63679

Histone H3 (1 - 25), amide
ARTKQTARKSTGGKAPRKQLATKAA - NH2

1 mg

61703

[Lys(Me3)9] - Histone H3 (3 - 17), H3K9(Me3) NEW
TKQTAR - K(Me3) - STGGKAPR

1 mg

64374-1

[Lys(Ac)14] - Histone H3 (9 - 19), H3K14(Ac)
KSTGG - K(Ac) - APRKQ

1 mg

63681




Product

Size

Catalog #

[Lys(Me1)9] - Histone H3 (3 - 17), H3K9(Me1) NEW
TKQTAR - K(Me1) - STGGKAPR

1 mg

64372-1

[Lys(Me2)9] - Histone H3 (3 - 17), H3K9(Me2) NEW
TKQTAR - K(Me2) - STGGKAPR

1 mg

64373-1

[Lys(Me3)9] - Histone H3 (3 - 17), H3K9(Me3) NEW
TKQTAR - K(Me3) - STGGKAPR

1 mg

64374-1




Product

Size

Catalog #

Histone H3 (23 - 34) NEW
KAARKSAPATGG

1 mg

64375-1

[Lys(Me1)27] - Histone H3 (23 - 34), H3K27(Me1) NEW
KAAR - K(Me1) - SAPATGG

1 mg

64376-1

[Lys(Me2)27] - Histone H3 (23 - 34), H3K27(Me2) NEW
KAAR - K(Me2) - SAPATGG

1 mg

64377-1

[Lys(Me3)27] - Histone H3 (23 - 34), H3K27(Me3) NEW
KAAR - K(Me3) - SAPATGG

1 mg

64378-1




Product

Size

Catalog #

[Lys(Me1)36] - Histone H3 (31 - 41), H3K36(Me1) NEW
STGGV - K(Me1) - KPHRY

1 mg

64379-1

[Lys(Me2)36] - Histone H3 (31 - 41), H3K36(Me2) NEW
STGGV - K(Me2) - KPHRY

1 mg

64380-1

[Lys(Me3)36] - Histone H3 (31 - 41), H3K36(Me3) NEW
STGGV - K(Me3) - KPHRY

1 mg

64381-1




Product

Size

Catalog #

Histone H3 (1 - 21), biotin-labeled
ARTKQTARKSTGGKAPRKQLA - GGK(Biotin) - NH2

1 mg

61702

[Lys(Me1)4] - Histone H3 (1 - 21) - GGK(Biotin), H3K4(Me1), biotin - labeled NEW
ART - K(Me1) - QTARKSTGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

64355-025

64355-1

[Lys(Me2)4] - Histone H3 (1 - 21) - GGK(Biotin), H3K4(Me2), biotin - labeled NEW
ART - K(Me2) - QTARKSTGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

64356-025

64356-1

[Lys(Me3)4] - Histone H3 (1 - 21) - GGK(Biotin), H3K4(Me3), biotin - labeled NEW
ART - K(Me3) - QTARKSTGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

64357-025

64357-1




Product

Size

Catalog #

[Lys(Me1)9] - Histone H3 (1 - 21) - GGK(Biotin), H3K9(Me1), biotin - labeled NEW
ARTKQTAR - K(Me1) - STGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

64358-025

64358-1

[Lys(Me2)9] - Histone H3 (1 - 21) - GGK(Biotin), H3K9(Me2), biotin - labeled NEW
ARTKQTAR - K(Me2) - STGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

64359-025

64359-1

[Lys(Me3)9] - Histone H3 (1 - 21) - GGK(Biotin), H3K9(Me3), biotin - labeled NEW
ARTKQTAR - K(Me3) - STGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

64360-025

64360-1

[Lys(Me2)9] - Histone H3 (1 - 21) - K(Biotin), H3K9(Me2), biotin labeled NEW
ARTKQTAR - K(Me2) - STGGKAPRKQLA - K(Biotin)

1 mg

63678




Product

Size

Catalog #

Histone H3 (21 - 44) - GK(Biotin), H3K27, biotin – labeled NEW
ATKAARKSAPATGGVKKPHRYRPG-GK(Biotin)

0.25 mg

1 mg

64440-025

64440-1

[Lys(Me1)27] - Histone H3 (21 - 44) - GK(Biotin), H3K27(Me1), biotin - labeled NEW
ATKAAR - K(Me1) - SAPATGGVKKPHRYRPG - GK(Biotin)

0.25 mg

1 mg

64365-025

64365-1

[Lys(Me2)27] - Histone H3 (21 - 44) - GK(Biotin), H3K27(Me2), biotin - labeled NEW
ATKAAR - K(Me2) - SAPATGGVKKPHRYRPG - GK(Biotin)

0.25 mg

1 mg

64366-025

64366-1

[Lys(Me3)27] - Histone H3 (21 - 44) - GK(Biotin), H3K27(Me3), biotin - labeled NEW
ATKAAR - K(Me3) - SAPATGGVKKPHRYRPG - GK(Biotin)

0.25 mg

1 mg

64367-025

64367-1




Product

Size

Catalog #

Histone H3 (21 - 44) - GK(Biotin), H3K27, biotin – labeled NEW
ATKAARKSAPATGGVKKPHRYRPG-GK(Biotin)

0.25 mg

1 mg

64440-025

64440-1

[Lys(Me1)36] - Histone H3 (21 - 44) - GK(Biotin), H3K36(Me1), biotin - labeled NEW
ATKAARKSAPATGGV - K(Me1) - KPHRYRPG - GK(Biotin)

0.25 mg

1 mg

64368-025

64368-1

[Lys(Me2)36] - Histone H3 (21 - 44) - GK(Biotin), H3K36(Me2), biotin - labeled NEW
ATKAARKSAPATGGV - K(Me2) - KPHRYRPG - GK(Biotin)

0.25 mg

1 mg

64442-025

64442-1

[Lys(Me3)36] - Histone H3 (21 - 44) - GK(Biotin), H3K36(Me3), biotin - labeled NEW
ATKAARKSAPATGGV - K(Me3) - KPHRYRPG - GK(Biotin)

0.25 mg

1 mg

64441-025

64441-1




Product

Size

Catalog #

[Lys(Ac)9] - Histone H3 (1 - 21) - GGK(Biotin), H3K9(Ac), biotin - labeled NEW
ARTKQTAR - K(Ac) - STGGKAPRKQLA - GGK(Biotin)

0.25 mg

1 mg

64361-025

64361-1

[Lys(Ac)9] - Histone H3 (1 - 21) - NH2, H3K9(Ac), biotin - labeled, amide NEW
ARTKQTAR - K(Ac) - STGGKAPRKQLA - GGK(Biotin) - NH2

1 mg

64190

[Lys(Ac)14] - Histone H3 (1 - 21) - GGK(Biotin), H3K14(Ac), biotin - labeled NEW
ARTKQTARKSTGG - K(Ac) - APRKQLA - GGK(Biotin)

0.25 mg

1 mg

64362-025

64362-1

[Lys(Ac)9/14] - Histone H3 (1 - 21) - GGK(Biotin), H3K9/14(Ac), biotin - labeled NEW
ARTKQTAR - K(Ac) - STGG - K(Ac) - APRKQLA - GGK(Biotin)

0.25 mg

1 mg

64363-025

64363-1

[pSer10), Lys(Ac)14] - Histone H3 (1 - 21) - GGK(Biotin), biotin - labeled NEW
ARTKQTARK - pS - TGG - K(Ac) - APRKQLAGGK(Biotin)

0.25 mg

1 mg

64364-025

64364-1

Related Products

Histone H1 Peptides

Histone H2A Peptides

Histone H4 Peptides

Histone Related Substrates

AnaSpec is the sole provider of the industry’s long wavelength HDAC assay kit, the SensoLyte 520 HDAC Activity Assay Kit. We also provide unusual amino acid building blocks such as Lys(Ac), Lys(Me1-3), Arg(Me2) , pSer and pThr for histone peptide synthesis.

References:

1. Grunstein, M. et al. J. Cell Sci. Suppl. 19, 29 (1995).
2. Strahl, BR and CD Allis, Nature 403, 41 (2000).
3. Strahl, BD. et al. Proc. Natl. Acad. Sci. 96, 14967 (1999).
4. Jenuwein, T. and CD. Allis Science 293, 1074 (2001).
5. Sterner, DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
6. Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).
7. Nishioka, K. et al. Genes & Dev. 16, 479 (2002).
8. Prigent, C. and S. Dimitrov, J. Cell Sci. 116, 3677 (2003).