ClearPoint™ β-Amyloid Peptides – Custom Service
world's largest provider of β-amyloid peptide and Alzheimer's research
reagents , is pleased to introduce our ClearPoint™ β-Amyloid
custom peptide synthesis service. ClearPoint™ peptides
are AnaSpec's trademark collection of heavy or stable isotope labeled peptides
and amino acids.
peptides offer a choice of heavy hydrogen (2H), carbon (13C),
or nitrogen (15N)-isotopes specifically labeled at single, multiple
or universal positions. With triple-stage validation (both mass spec & HPLC)
and over 10 years of successful synthesis, ClearPoint™ peptides are the proven
solution for optimum quality heavy isotope labeled peptides.
peptides can be used for the quantitative analyses of β-Amyloid peptides in biological fluids using
mass spectrometry (MS). The inclusion of internal heavy isotope labeled peptide
standards makes mass spectrometry an absolute quantitation (AQUA) method for
the peptide of interest.1
β-Amyloid (1-40) and (1-42) peptides have been
used as biomarkers of Alzheimer's disease (AD). Historically, ELISA assays have
been used in the quantitation of these peptides. However, technical challenges
such as the tendency of β-Amyloid (1-40) and (1-42)
peptides to self-aggregate, undergo post-translational modifications or bind
to other proteins often result in inaccuracies in quantitation when using ELISA.2
Oe, et al. reported the use of [15N]-labeled β-Amyloid
peptides as internal standards using immunoaffinity purified CSF.2
request a quotation, please click here or contact email@example.com.
is a select listing of off-the-shelf GO® versions of our ClearPoint™ β-Amyloid
peptides. For a full listing, please click here.
Harding, S. (ed.) 2007. Biotechnology & Genetic Engineering Reviews. Nottingham
Univ. Press, Nottingham.
2. Oe, T. et al. Rapid Comm. Mass Spec. 20, 3723 (2006).