Ghrelin Peptides are GO

AnaSpec, EGT Group, a leading provider of integrated proteomic and genomic solutions, offers ghrelin GO (catalog) peptides for research use.

In 1999, Kojima and his group (1) reported the discovery of a growth hormone secretagogue that is involved in the release of growth hormone from the anterior pituitary through activation of the growth hormone secretagogue receptor (GHS-R), which they termed Ghrelin (ghre from a Proto-Indo-European root meaning to grow). Ghrelin, a 28-amino-acid peptide hormone produced by the stomach of mammals, is a peptide with an n-octanoyl modification at Ser3 (n-octanoylation is essential for its activity). It stimulates appetite and food intake and decreases fat utilization. The secretion of ghrelin is augmented under conditions of both gastric emptying and filling, and its release stimulated by intestinal hormones (1-5).

Table 1. Human ghrelin peptides.

Product

Size

Catalog #

Ghrelin, human
GS-S(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR

1 mg

5 mg

24157

24158

[Des-octanoyl]-Ghrelin, human
GSSFLSPEHQRVQQRKESKKPPAKLQPR

1 mg

61177

Biotin-Ghrelin, human
Biotin-GS-S(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR

1 mg

29391

Table 2. Rat Ghrelin peptides

Product

Size

Catalog #

Ghrelin, rat
GS-S(n-octanoyl)-FLSPEHQKAQQRKESKKPPAKLQPR

1 mg

5 mg

24159

24160

[Des-octanoyl]-Ghrelin, rat
GSSFLSPEHQKAQQRKESKKPPAKLQPR

1 mg

60981

References:
1. Kojima, M. et al. Nature 402, 656 (1999).
2. Kleinz, MJ. et al. Cardiovasc Res. 69, 227 (2006).
3. Murakami, N. et al. J. Endocrinol. 174, 283 (2002).
4. Nishi, Y. et al. Endocrinol. 146, 2709 (2005).
5. Cowley, MA. et al. Neuron 37, 649 (2003).
6. Zhang, JV. et al. Science 310, 996 (2005).