Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  Amyloid Peptides  >  Beta-Amyloid Peptide Fragments  >>  Beta-Amyloid (1-16), Human

Product Name Beta - Amyloid (1 - 16), Human
DAEFRHDSGYEVHHQK
Size 1 mg
Catalog # AS-24225
US$ $83
Purity % Peak Area By HPLC ≥ 95%
Description

Proteins interactions with reactive oxygen agents may result in covalent modifications of amino acid residues in proteins, formation of protein-protein cross-linkages and oxidation of the protein backbone resulting in protein fragmentation. Oxidation targets for Aß(1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aß in senile plaque of Alzheimer’s disease with Aß (1-16) taking part in the coordination of the Cu2+ ions. Cu2+ and Zn2+ are linked with the neurotoxicity of Aß and free radical damage.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Da Silva, GFZ. et al. J. Biol. Chem. 280, 16601 (2005); Kowalik-Jankowska, T. et al. J. Inorg. Biochem. 98, 940 (2004); Kowalik-Jankowska, T. et al. J. Inorg. Biochem. 95, 270 (2003).
Molecular Weight 1955
Sequence
(One-Letter Code)
DAEFRHDSGYEVHHQK
Sequence
(Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - OH
Product Citations Miller, A. et al. (2011). Behavior of β-amyloid 1-16 at the air-water interface at varying pH by nonlinear spectroscopy and molecular dynamics simulations. J Phys Chem 10.1021/jp110103j.
Minicozzi, V. et al. (2008). Identifying the minimal Cu and Zn binding site sequence in amyloid beta peptides. J Biol Chem 10.1074/jbc.M707109200.
Solorzano-Vargas, R.S. et al. (2008). Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42. Mol Immunol 45, 881.
Osada, Y. et al. (2004). CLAC binds to amyloid β peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J Biol Chem 280, 8596.
Cottingham, MG. et al. (2004). Rapid method for measurement of surface tension in multiwell plates. Lab Methods 84, 523.
     
  < Back