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Peptides  >  Amyloid Peptides  >  Beta-Amyloid (1-40) and Related Peptides  >>  Beta-Amyloid (1-40) HCl, Human

Product Name Beta - Amyloid (1 - 40) HCl, Human
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV HCl
Size 0.5 mg
Catalog # AS-23211
US$ $181
Purity % Peak Area By HPLC ≥ 95%
Description

All the HCl salt forms of A (1-40), A (25-35) and D-Ser26 A (25-35), take the -structure within a few hours in PBS. They form fibrils, exert toxic effects on hippocampal cultured neurons and suppress MTT reduction activity of non-neuronal (HeLa) cells without cytotoxicity.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Kaneko, I. et al. Nippon Yakurigaku Zasshi. 115, 67 (2000).
Molecular Weight 4329.936.5
Sequence
(One-Letter Code)
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV HCl
Sequence
(Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - OH HCl
Product Citations Andrs, IE. et al. (2014). Transcriptional Profile of HIV-induced Nuclear Translocation of Amyloid β in Brain Endothelial Cells. Arch Med Res doi: 10.1016/j.arcmed.2014.11.003.
Edwin, NJ. et al. (2010). Reversibility of β-amyloid self-assembly: Effects of pH and added salts assessed by fluorescence photobleaching recovery. Biomacromolecules 11, 341. doi: 10.1021/bm900833b.
Qiao, H. et al. (2005). Inhibition of Alzheimer's amyloid-β peptide-induced reduction of mitochondrial membrane potential and neurotoxicity by gelsolin. Neurobiol Aging 26, 849. doi: 10.1016/j.neurobiolaging.2004.08.003.
Takuma, H. et al. (2004). Amyloid beta peptide‐induced cerebral neuronal loss is mediated by caspase‐3 in vivo. J Neuropathol Exp Neurol 63, 255.
Nishimura, S. et al. (2003). RS‐4252 Inhibits Amyloid β‐Induced Cytotoxicity in HeLa Cells. Pharmacol Toxicol 93, 29. doi: 10.1034/j.1600-0773.2003.930104.x.
Kakimura, J-I. et al. (2002). Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. FASEB J. 10.1096/fj.01-0530fje.
Kubo, T. et al. (2002). Amyloid β-peptide alters the distribution of early endosomes and inhibits phosphorylation of Akt in the presence of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT). Mol Brain Res 106, 94. doi: 10.1016/S0169-328X(02)00416-3.
     
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