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Peptides  >  Amyloid Peptides  >  Beta-Amyloid Peptide Fragments  >>  Acetyl [Pro18, Asp21]-beta-Amyloid (17-21), amide, iAb5p Pro18 Asp21, Human, mouse/rat

Product Name Acetyl [Pro18, Asp21] - beta - Amyloid (17 - 21), amide, iAb5p Pro18 Asp21, Human, mouse/rat
Ac - LPFFD - NH2
Size 1 mg
Catalog # 61174
US$ $66
Purity % Peak Area By HPLC ≥ 95%
Description

This 5-residue synthetic peptide inhibits and disassembles amyloid fibrils in-vitro; prevents Aß neurotoxicity in cell culture; arrests deposition of amyloid lesions and induces dissolution of preformed plaques in a rat brain model of amyloidosis. With N- and C-terminal protections to minimize exopeptidase cleavage, this peptide is rapidly taken up by the brain and reduces in-vivo amyloid deposition and cerebral damage in a double transgenic animal model of Alzheimer’s disease.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20°C
References Ref: Permanne, B. et al. FASEB J. 16, 860 (2002); Adessi, S. et al. J. Biol. Chem. 278, 13905 (2003).
Molecular Weight 678.8
Sequence
(One-Letter Code)
Ac-LPFFD-NH2
Sequence
(Three-Letter Code)
Ac - Leu - Pro - Phe - Phe - Asp - NH2
     
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