Magainin 2 assumes an amphiphilic helix when bound to acidic phospholipids, forming a pore composed of a dynamic, peptide-lipid supramolecular complex.
Ref: Zasloff, M. Proc. Natl. Acad. Sci. USA. 84, 5449 (1987); Cruciani, RA. et al. EJPMOL 8, 187 (1992); Corzo, G. et al. Biochem. J. 359, 35 (2001); Matsuzaki, K. et al. Biochem. 36, 2104 (1997).
Molecular Weight
2466.9
Sequence (One-Letter Code)
GIGKFLHSAKKFGKAFVGEIMNS
Sequence (Three-Letter Code)
H - Gly - Ile - Gly - Lys - Phe - Leu - His - Ser - Ala - Lys - Lys - Phe - Gly - Lys - Ala - Phe - Val - Gly - Glu - Ile - Met - Asn - Ser - OH