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Peptides  >  Thrombin Related Peptides  >>  Thrombin Receptor (42-48) Agonist, human

Product Name Thrombin Receptor (42 - 48) Agonist, human
SFLLRNP
Size 1 mg
Catalog # AS-24169
US$ $44
Purity % Peak Area By HPLC ≥ 95%
Description

Thrombin binds to its receptor's long N-terminal extracellular extension and cleaves the peptide bond between Arg-41 and Ser-42. The newly exposed N-terminal moiety starting from SFLLRNP acts as a tethered ligand to activate the receptor. It can also stimulate phosphoinositide turnover because the extent of phosphoinositide hydrolysis is directly proportional to the concentration of thrombin. The phenylalanine residue at position 2 is known to play a crucial role in the activation of the thrombin receptor in an intramolecular manner. On the other hand, agonist peptides incorporating the amino acid sequence (SFLLRNP) of the newly exposed N-terminal portion of the cleaved receptor cause receptor activation without requiring prior cleavage of the receptor by thrombin.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References 1, Nose T. et al. BBRC, 193(2):694-699 (1993).
2, Molloy, C. et al. J. Clin. Invest. 97, 1173 (1996).
3, Ishida, A. et al. FEBS Lett. 427, 155 (1998).
4, Ishida, A. and H. Fujisawa, J. Biol. Chem. 270, 2163 (1995).
Molecular Weight 846
Sequence
(One-Letter Code)
SFLLRNP
Sequence
(Three-Letter Code)
H - Ser - Phe - Leu - Leu - Arg - Asn - Pro - OH
Product Citations Ludeman, M. et al. (2004). Regulated Shedding of PAR1 N-terminal Exodomain from Endothelial Cells. J Biol Chem 279, 18592.
     
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