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Peptides  >  Toxins  >>  Iberiotoxin (IbTX)

Product Name Iberiotoxin (IbTX)
Pyr - FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ(Disulfide bridge: C7 - C28,C13 - C33,C17 - C35)
Size 0.1 mg
Catalog # 60763
US$ $159
Purity % Peak Area By HPLC ≥ 95%
Description

A 37-amino acid peptide from the scorpion, Buthus tamulus, having 68% homology with charybdotoxin. It is a selective inhibitor of the highly conductance calcium-activated (maxi-K) potassium channels.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
References Galvez, A. et al. J. Biol. Chem. 265, 11083 (1990). Candia, S. et al. Biophys. J. 63, 583 (1992).
Molecular Weight 4230.9
Sequence
(One-Letter Code)
Pyr-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ(Disulfide bridge: C7-C28,C13-C33,C17-C35)
Sequence
(Three-Letter Code)
Pyr - Phe - Thr - Asp - Val - Asp - Cys - Ser - Val - Ser - Lys - Glu - Cys - Trp - Ser - Val - Cys - Lys - Asp - Leu - Phe - Gly - Val - Asp - Arg - Gly - Lys - Cys - Met - Gly - Lys - Lys - Cys - Arg - Cys - Tyr - Gln - OH (Disulfide bridge: C7 - C28,C13 - C33,C17 - C35)
Product Citations Burke, M. et al. (2013). Genetic basis of the impaired renal myogenic response in FHH rats. Am J Physiol Renal Physiol 304, F565. doi: 10.​1152/​ajprenal.​00404.​2012.
Stoneking, CJ. et al. (2013). Voltage dependence of the Ca2+-activated K+ channel KCa3. 1 in human erythroleukemia cells. Am J Physiol-Cell Physiol 304 C858.
Vang, A. et al. (2010). Activation of endothelial BKCa channels causes pulmonary vasodilation. Vas Pharmacol doi:10.1016/j.vph.2010.05.00.
Houamed, KM. et al. (2010). BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells. J Physiol 588 3511. doi: 10.1113/jphysiol.2009.184341.
     
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