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Peptides  >  Toxins  >>  Sarafotoxin 6c

Product Name Sarafotoxin 6c
CTCNDMTDEECLNFCHQDVIW (Disulfide bridge: 1 - 15 and 3 - 11)
Size 1 mg
Catalog # 24326
US$ $341
Purity % Peak Area By HPLC ≥ 95%
Description

This selective ET receptor subtype B agonist is a vasoconstrictor peptide. In experiments on renal vasoconstrictor actions, sarafotoxin 6c appears to be potent at the renal resistance vasculature and is powerfully modulated by NO. It plays a role in cytosolic Ca2+ concentration ([Ca2+]i) balance.The differences between central helix of the endothelin and sarafotoxin isopeptides might be important in binding of these ligands by the G protein-coupled endothelin receptors.

Storage -20C
References Ref: Mills, R. et al. J. Biol. Chem. 269, 23413 (1994); Watanabe, C. et al. Br. J. Pharmacol. 108, 30 (1993); Marshall, JL. and JJ. Edward, Br. J. Pharmacol. 128, 809 (1999).
Molecular Weight 2515.8
Sequence
(One-Letter Code)
CTCNDMTDEECLNFCHQDVIW (Disulfide bridge: 1-15 and 3-11)
Sequence
(Three-Letter Code)
H - Cys - Thr - Cys - Asn - Asp - Met - Thr - Asp - Glu - Glu - Cys - Leu - Asn - Phe - Cys - His - Gln - Asp - Val - Ile - Trp - OH (Disulfide bridge: 1 - 15 and 3 - 11)
Product Citations Eskesen, K. and L. Edvinsson Eur. J. Pharma. 539, 192 (2006).
     
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