This native Melan-A (26-35) decapeptide is an immunodominant antigen from melanocyte/melanoma (Melan-A/MART) protein that is more efficiently recognized by tumor-infiltrating lymphocytes (TILs) of melanoma patients than the Melan-A (27-35), but has lower binding affinity and stability than the ELAGIGILTV analog.
Ref: Pinilla, C. et al. Cancer Res. 61, 5153 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Ala - Ala - Gly - Ile - Gly - Ile - Leu - Thr - Val - OH