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Peptides  >  Exendins  >>  Exendin 4

Product Name Exendin 4
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS - NH2
Size 0.5 mg
Catalog # AS-24463
US$ $83
Purity % Peak Area By HPLC ≥ 95%
Description

Exendin-4, an agonist of glucagon-like peptide 1 (GLP-1) receptor, induces release of insulin after food intake. Exendin-4 shares a 53% sequence homology with GLP-1. Derived from Gila monster, Heloderma suspectum, Exendin-4 has a longer half life than GLP-1 in the plasma, thus making it a more potent insulinotropic agent.

Detailed Information Datasheet
Storage -20°C
References Eng, J. et al. J Biol Chem 267, 7402 (1992)
Greig, NH. et al. Diabetolog 42, 45 (1999)
Göke R. et al. J Biol Chem 268, 19650 (1993)
Molecular Weight 4186.6
Sequence
(One-Letter Code)
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
Sequence
(Three-Letter Code)
H - His - Gly - Glu - Gly - Thr - Phe - Thr - Ser - Asp - Leu - Ser - Lys - Gln - Met - Glu - Glu - Glu - Ala - Val - Arg - Leu - Phe - Ile - Glu - Trp - Leu - Lys - Asn - Gly - Gly - Pro - Ser - Ser - Gly - Ala - Pro - Pro - Pro - Ser - NH2
Product Citations Potthoff, MJ. et al. (2013). Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol 304, G371. doi: 10.​1152/​ajpgi.​00400.​2012.
Ding, J. et al. (2009). Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating GLP-1 in mice. Endocrin. doi:10.1210/en.2008-1006.
Sordi, V. et al. (2009). Mesenchymal Cells Appearing in Pancreatic Tissue Culture Are Bone Marrow-Derived Stem Cells With the Capacity to Improve Transplanted Islet Function. Stemm Cells 28, 140.
Sharma, A. et al. (2006). Exendin-4 treatment improves metabolic control after rat islet transplantation to athymic mice with streptozotocin-induced diabetes. Diabetologia 49, 1247.
     
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