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Peptides  >  Thrombospondins  >>  LSKL, Inhibitor of Thrombospondin (TSP-1)
Product Name LSKL, Inhibitor of Thrombospondin (TSP - 1)
Size 1 mg
Catalog # 60877
US$ $66
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide, derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-ß; thus preventing the progression of hepatic damage and fibrosis.
Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Ref: Ribeiro, SM. et al. J. Biol. Chem. 274, 13586 (1999); Kondou, H. et al. J. Hepatol. 39, 742 ( 2003).
Molecular Weight 458.6
Sequence
(One-Letter Code)		 LSKL-NH2
Sequence
(Three-Letter Code)		 H - Leu - Ser - Lys - Leu - NH2
Product Citations Wang, S. et al. (2010). Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-β activity in vascular smooth muscle cells. Am J Physiol Cell Physiol doi:10.1152/ajpcell.00330.2009
Xie, X. et al. (2010). LSKL, a peptide antagonist of thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction. Archives Pharmac Research 33, 275.
Belmadani, Souad. A. J. Pathology. 171, 777 (2007).
Zhou, Y. et al. Am. J. Pathol. 165, 659 (2004).
Meek, R. L. et al. Am J Physiol Renal Physiol. 285, 79 (2003).
     
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