This peptide corresponds to human keratin K18 amino acids 26-38, with an additional C-terminal cysteine. The sequence is identical to mouse K18 except that human K18 Val28 is replaced by alanine in the mouse sequence. Members of the 14-3-3 protein family bind the human intermediate filament protein keratin 18 (K18) in-vivo, in a cell-cycle- and phosphorylation-dependent manner. K18 Ser33 phosphorylation is essential for the association of K18 with 14-3-3 proteins and plays a role in keratin organization and distribution.
Ref: Ku, NO. et al. EMBO J. 17, 1892 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Pro - Val - Ser - Ser - Ala - Ala - pSer - Val - Tyr - Ala - Gly - Ala - Cys - OH