The native peptide, PLARTLSVAGLPGKK (cat# 22511), is a selective substrate for CaM kinase II and protein kinase C. It is a poor substrate for phosphorylase kinase and is not phosphorylated by myosin light chain kinase. The sequence of PLARTLSVAGLPGKK is homologous to phosphorylation site 2 in glycogen synthase. The relative Vmax/Km ratios of the peptide for different kinases are 100 for CaMK II, 22 for protein kinase C, 2 for phosphorylase kinase, and 0.5 for myosin light chain kinase respectively.
Ref: Kumar KA. and Babu PP. Neurosci. Lett. 336, 121 (2003); Inoue S. et al. Biochem. Biophys. Res. Commun. 215, 861 (1995); Hashimoto, Y. and TR. Soderling, Arch. Biochem. Biophys. 252, 418 (1987).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Pro - Leu - Ala - Arg - Thr - Leu - Ser - Val - Ala - Gly - Leu - Pro - Gly - Lys - Lys - OH