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Peptides  >  Phosphopeptides  >>  Angiotensin II Substrate

Product Name Angiotensin II Substrate
DRV - pY - IHPF
Size 5 mg
Catalog # AS-24521
US$ $946
Purity % Peak Area By HPLC ≥ 95%
Description

This is a tyrosine phosphorylated angiotensin II peptide with a substrate sequence specificity for chymase to act. This is an octapeptide hormone that is formed as a result of the action of human heart chymase, a chymotrypsin-like serine protease on the Phe-His bond of Angiotensin I. The ideal susbtrate for human heart chymase should contain this peptide sequence, and has been demonstrated that the Pro-Phe sequence in P2-P1 positions of peptide substrates is highly favored by leukocyte chymotrypsin-like proteinases such as chymases and cathepsin G.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References 1, Kinoshita A, et al. J Biol Chem 266(29): 19192-19197 (1991).
2, Ruzzene, M. et al. Eur. J. Biochem. 211, 289 (1993).
Molecular Weight 1126.2
Sequence
(One-Letter Code)
DRV-pY-IHPF
Sequence
(Three-Letter Code)
H - Asp - Arg - Val - pTyr - Ile - His - Pro - Phe - OH
Product Citations Crowe, MC. and Brodbelt, JS. (2004). Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociation of peptides in a quadrupole ion trap with selective IRMPD of phosphopeptides. J. Am. Soc. for Mass Spectrom 15, 1581. doi: 10.1016/j.jasms.2004.07.016.

Woods, A. S. et al. J. (2003). Angiotensin II–Acetylcholine noncovalent complexes analyzed with MALDI–Ion mobility–TOF MS. Biomol. Tech 14, 1.
     
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