This is an experimentally defined model peptide for the fibril formation from the core residues of the beta-Amyloid peptides of Alzheimer's disease. This peptide adopts the structure of an extended parallel beta-sheet at pH 7.4 in high-resolution structural studies.
Lakdawala, A. et al. Am. Chem. Soc. 124, 15150 (2002); Benzinger, S. et al. Biochem. 39, 3491 (2000); Trzesniewska, K.et al. Acta Neurobiol. Exp. 64, 41 (2004).
Molecular Weight
2903.4
Sequence (One-Letter Code)
YEVHHQKLVFFAEDVGSNKGAIIGLM
Sequence (Three-Letter Code)
H - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - OH
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