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Peptides  >  Signal Transduction Peptides  >>  JAG-1 (188-204), Jagged-1 (188-204), Notch Ligand, DSL Peptide

Product Name JAG - 1 (188 - 204), Jagged - 1 (188 - 204), Notch Ligand, DSL Peptide
CDDYYYGFGCNKFCRPR
Size 1 mg
Catalog # AS-61298
US$ $171
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-κB activation.

Related Product: Jagged-1, scrambled, cat# 64239

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
References Nickoloff, B. et al. Cell Death Different. 9, 842 (2002).
Molecular Weight 2107.4
Sequence
(One-Letter Code)
CDDYYYGFGCNKFCRPR
Sequence
(Three-Letter Code)
H - Cys - Asp - Asp - Tyr - Tyr - Tyr - Gly - Phe - Gly - Cys - Asn - Lys - Phe - Cys - Arg - Pro - Arg - OH
Product Citations Cioff, S. et al. (2013). Tbx1 regulates brain vascularization. Hum Mol Genet doi: 10.1093/hmg/ddt400.
Onuma, K. et al. (2013). Genetic reconstitution of tumorigenesis in primary intestinal cells. PNAS 110, 11127. doi: 10.1073/pnas.1221926110.
Wang, F. et al. (2013). Isolation and Characterization of Intestinal Stem Cells Based on Surface Marker Combinations and Colony-Formation Assay. Gastroenterol 145, 383. doi: 10.1053/j.gastro.2013.04.050.
VanDussen, KL. et al. (2012). Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development 139, 488. doi: 10.1242/dev.070763.
Van Landeghem, L. et al. (2012). Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation. Am J Physiol Gastrointest Liver Physiol 302, G1111. doi: 10.1152/ajpgi.00519.2011.
Fox, RG. et al. (2012). Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. Am J Physiol Gastrointest Liver Physiol 302, G914. doi: 10.1152/ajpgi.00402.2011.
Ramalingam, S. et al. (2012). Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture. Am J Physiol Gastrointest Liver Physiol 302, G10. doi: 10.1152/ajpgi.00277.2011.
Yao, H. et al. (2011). Platelet-derived growth factor B chain is a novel target gene of cocaine-mediated Notch1 signaling: Implications for HIV-associated neurological disorders. J Neurosci 31, 12449. doi: 10.1523/JNEUROSCI.2330-11.2011.
Gracz, AD. et al. (2010). Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro. Am J Physiol Gastrointest Liver Physiol 298, G590. doi: 10.1152/ajpgi.00470.2009.
Ma, X-B. et al. (2009). Expression and role of Notch signalling in the regeneration of rat tracheal epithelium. Cell Proliferation 42, 15.
Sainson, RCA. et al (2005). Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB Journal 19, 1027.
     
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