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Peptides  >  Signal Transduction Peptides  >>  JAG-1 (188-204), Jagged-1 (188-204), Notch Ligand, DSL Peptide
Product Name JAG - 1 (188 - 204), Jagged - 1 (188 - 204), Notch Ligand, DSL Peptide
Size 1 mg
Catalog # 61298
US$ $171
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-κB activation.
Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Nickoloff, B. et al. Cell Death Different. 9, 842 (2002).
Molecular Weight 2107.4
Sequence
(One-Letter Code)		 CDDYYYGFGCNKFCRPR
Sequence
(Three-Letter Code)		 H - Cys - Asp - Asp - Tyr - Tyr - Tyr - Gly - Phe - Gly - Cys - Asn - Lys - Phe - Cys - Arg - Pro - Arg - OH
Product Citations Ma, X-B. et al. (2009). Expression and role of Notch signalling in the regeneration of rat tracheal epithelium. Cell Proliferation 42, 15.
Sainson, R.C.A. et al (2005). Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB Journal 19, 1027.
     
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