Peptides  >  Amyloid Peptides  >  Beta-Amyloid Peptide Fragments  >>  [Ac-Lys(Me)¹⁶, N-Me-Val¹⁸]-beta-Amyloid (16-20)-NH₂

This membrane permeable N-methyl amino acid-containing peptide inhibits b-amyloid 1 to 40 fibrillogenesis. Its structure is remarkably stable to changes in solvent conditions and resists denaturation by heating, changes in pH (from 2.5 to 10.5), and addition of denaturants such as urea and guanindine-HCl. The striking water solubility, in combination with the hydrophobic composition of the peptide, allows the peptide to pass spontaneously through cell membranes.