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Peptides  >  Amyloid Peptides  >  Beta-Amyloid (1-42) and Related Peptides  >>  [Lys22]-beta-Amyloid (1-42), Italian Mutation, Human

Product Name [Lys22] - beta - Amyloid (1 - 42), Italian Mutation, Human
DAEFRHDSGYEVHHQKLVFFAKDVGSNKGAIIGLMVGGVVIA
Size 0.5 mg
Catalog # 62148
US$ $264
Purity % Peak Area By HPLC ≥ 95%
Description

This is amino acids 1 to 42 fragment of the beta-amyloid peptide, with lysine substituted for glutamic acid at position 22 found in Italian families with Alzheimer's disease. The Italian mutation of beta -amyloid 1 to 42 (E22K) aggregates more rapidly and with more potent neurotoxicity than wild-type beta-amyloid (1-42). The formation of a salt bridge between Lys22 and Asp23 in the minor conformer might be a reason why E22K is more pathogenic than wild-type beta-amyloid (1-42).

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
References Masuda, Y. et al. Bioorg. Med. Chem. 13, 6803 (2005).
Molecular Weight 4513.2
Sequence
(One-Letter Code)
DAEFRHDSGYEVHHQKLVFFAKDVGSNKGAIIGLMVGGVVIA
Sequence
(Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Lys - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - Ile - Ala - OH
     
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