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Peptides  >  Amyloid Peptides  >  Amyloid Precursor Protein (APP) / Amyloid Precursor-like Protein (APLP)  >>  Amyloid Precursor Protein, (APP) (667-676), FRET peptide

Product Name Amyloid Precursor Protein, (APP) (667 - 676), FRET peptide
Mca - SEVKMDAEFR - Dap(Dnp) - NH2
Size 1 mg
Catalog # 62075
US$ $253
Purity % Peak Area By HPLC ≥ 95%
Description

This amino acids 667 to 676 fragment of the amyloid precursor protein (APP) is a beta secretase substrate containing an Mca/ Dap(Dnp) FRET pair. Beside being cleaved by beta-site APP cleavage enzyme (BACE) between the Met and Asp residues, it can also be cleaved by the enzyme thimet oligopeptidase (TOP), Ex/Em=330 nm/390 nm.

Storage -20°C
References Koike, H. et al. J. Biochem. 126, 235 (1999), Grüninger-Leitch, F. et al. J. Biol. Chem. 277, 4687 (2002), Verheijen, J. et al. Clin. Chem. 52, 1168 (2006).
Molecular Weight 1678.8
Sequence
(One-Letter Code)
Mca-SEVKMDAEFR-Dap(Dnp)-NH2
Sequence
(Three-Letter Code)
Mca - Ser - Glu - Val - Lys - Met - Asp - Ala - Glu - Phe - Arg - DAP(DNP) - NH2
     
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