This is a PUMA (p53 upregulated modulator of apoptosis) BH3 domain peptide. PUMA together with Bcl-xL, and cytoplasmic p53 coordinates p53 functions. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Storage
-20°C
References
Chipuk, J. et al. Science 309, 1732 (2005), Nakano, K. et al. Mol. Cell 7, 683 (2001), Yu, J. et al. Mol. Cell 7, 673 (2001), Han, J. et al. Proc. Natl. Acad. Sci. U S A. 98, 11318 (2001).
Molecular Weight
3049.3
Sequence (One-Letter Code)
EEQWAREIGAQLRRMADDLNAQYER
Sequence (Three-Letter Code)
H - Glu - Glu - Gln - Trp - Ala - Arg - Glu - Ile - Gly - Ala - Gln - Leu - Arg - Arg - Met - Ala - Asp - Asp - Leu - Asn - Ala - Gln - Tyr - Glu - Arg - OH
