This is a T-cell immunodominant CD8 peptide of the Ag85A Mycobacterium tuberculosis protein, MHC class I H-2Ld-restricted epitope. Because parenterally administered Mycobacterium bovis BCG vaccine confers only limited immune protection from pulmonary tuberculosis, intranasal administration of vector expressing AdAg85A represents an effective way to boost immune protection by parenteral BCG vaccination.
Santosuosso, M. et al. Infect. Immun.74, 4634 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Leu - Thr - Ser - Glu - Leu - Pro - Gly - Trp - Leu - Gln - Ala - Asn - Arg - His - Val - Lys - Pro - Thr - Gly - Ser - OH