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Peptides  >  Cell Adhesion Peptides  >>  37, 40 GAP26, Connexin Mimetic

Product Name 37, 40 GAP26, Connexin Mimetic
VCYDQAFPISHIR
Size 1 mg
Catalog # AS-62639
US$ $83
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide corresponds to the GAP26 domain of the extracellular loop of the major vascular connexins (Cx37, Cx40), designated as 37,40Gap 26 according to Cx homology. It was used to investigate the role of gap junctions in the spread of endothelial hyperpolarizations evoked by cyclopiazonic acid (CPA) through the wall of the rodent iliac artery. The gap junction plaques constructed from Cx37 and Cx40 were abundant in the endothelium. This peptide provides inhibitory effects against subintimal hyperpolarization.

Storage -20C
References Chaytor, A. et al. British J. Pharmacol. 144, 108 (2005), Griffith, T. et al. PNAS 102, (7008).
Molecular Weight 1548.8
Sequence
(One-Letter Code)
VCYDQAFPISHIR
Sequence
(Three-Letter Code)
H - Val - Cys - Tyr - Asp - Gln - Ala - Phe - Pro - Ile - Ser - His - Ile - Arg - OH
Product Citations Yi, FX. et al. (2010). Pregnancy Enhances Sustained Ca2+ Bursts and Endothelial Nitric Oxide Synthase Activation in Ovine Uterine Artery Endothelial Cells Through Increased Connexin 43 Function. Biol Reprod 82, 66.
     
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