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Peptides  >  Thrombin Related Peptides  >>  Protease-Activated Receptor-1, PAR-1 Agonist, amide

Product Name Protease - Activated Receptor - 1, PAR - 1 Agonist, amide
TFLLRNPNDK - NH2
Size 1 mg
Catalog # AS-62936
US$ $66
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.

Storage -20C
References Vogel, SM. et al. Physiol. Genom. 4:137-145 (2000).
Molecular Weight 1216.4
Sequence
(One-Letter Code)
TFLLRNPNDK-NH2
Sequence
(Three-Letter Code)
H - Thr - Phe - Leu - Leu - Arg - Asn - Pro - Asn - Asp - Lys - NH2
Product Citations Kouzaki, H. et al. (2013). Transcription of Interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells J. Resp. Cell. Mol. Biol49(5):741-750. doi: 10.1165/rcmb.2012-0304OC

Mosnier, L. O. (2012). Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 Blood doi: http://dx.doi.org/10.1182/blood-2012-08-452169.

Wang, W. et al. (2009). Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1. Int J Cancer126, 599. doi: 10.1002/ijc.24904.
     
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