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Peptides  >  Histones  >  Histone H1 Peptides  >>  Histone H1 (22-42), human, mouse

Product Name Histone H1 (22 - 42), human, mouse
STDHPKYSDMIVAAIQAEKNR
Size 1 mg
Catalog # AS-63674
US$ $176
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is part of the Histone 1 molecule obtained from MHC class II molecules of an antigen-presenting cell line fed with crude chromatin from lupus-prone mice. The H1'22-42 has been shown to be a potent stimulator of autoimmune T-helper cells and accelerated lupus nephritis when administered to lupus-prone mice. The H1′2242 epitope was also found to be recognized by autoimmune B cells, and it's serum autoantibodies were shown to be increasingly cross reactive with nuclear autoantigens upon onset of lupus nephritis.

Storage -20C
References Kaliyaperumal, A. et al. J. Immunol. 168, 2530 (2002).
Molecular Weight 2374.7
Sequence
(One-Letter Code)
STDHPKYSDMIVAAIQAEKNR
Sequence
(Three-Letter Code)
H - Ser - Thr - Asp - His - Pro - Lys - Tyr - Ser - Asp - Met - Ile - Val - Ala - Ala - Ile - Gln - Ala - Glu - Lys - Asn - Arg - OH
     
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