This is the amino acids 1 to 16 fragment of the human Tau protein. Amyloid pathology is accompanied by the presence of various isoforms of this human protein in neurofibrillary tangles. This peptide was used as an immunogen to develop the anti-Tau antibody BR133.
Spillantini, M. et al. Proc. Natl. Acad. Sc.87, 3947 (1990).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Met - Ala - Glu - Pro - Arg - Gln - Glu - Phe - Glu - Val - Met - Glu - Asp - His - Ala - Gly - OH