This is amino acid sequence of rat C-peptide-1. C-peptide binds specifically to cell surfaces, probably to a G protein-coupled surface receptor, with subsequent activation of Ca2+-dependent intracellular signaling pathways. It also stimulates Na+-K+-ATPase and endothelial nitric oxide synthase activities. Rat C-peptide was found to diminish glucose-stimulated insulin release in rats both in vivo and in vitro.
Wahren, J. et al. Am. J. Physiol Endocrinol Metab. 278, E759 (2000).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Val - Glu - Asp - Pro - Gln - Val - Pro - Gln - Leu - Glu - Leu - Gly - Gly - Gly - Pro - Glu - Ala - Gly - Asp - Leu - Gln - Thr - Leu - Ala - Leu - Glu - Val - Ala - Arg - Gln - OH