This is a synthetic substrate for insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase domain with a low Km (26±3.9µM) for binding. This peptide sequence is based on the position of tyrosine in the sequence (phosphorylation site: Y895) of Insulin receptor substrate-1 (IRS-1) protein. The YVNI site within the sequence is important for binding to SH2 domains.
1, Xu B. et al. J Biol Chem, 270(50):29825 (1995). 2, Favelyukis S. et al. Nat Struct Biol. 8:1058 (2001)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Lys - Lys - Ser - Pro - Gly - Glu - Tyr - Val - Asn - Ile - Glu - Phe - Gly - OH