This is amino acids 494 to 513 fragment of endothelial nitric oxide synthase (eNOS) calmodulin (CaM)-binding region. The enzyme NOS is exquisitely regulated in vivo by the calcium sensor protein calmodulin to control production of NO, a key signaling molecule and cytotoxin.
Aoyagi, M. et al. EMBO J. 22, 766 (2003); Frederick, K. et al. Nature 448, 325 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Lys - Lys - Thr - Phe - Lys - Glu - Val - Ala - Asn - Ala - Val - Lys - Ile - Ser - Ala - Ser - Leu - Met - Gly - OH